Compositions and Methods for Improving Toughness of Irradiated Sterilized Bone Allografts
AssigneeSinai Health System
InventorThomas Willett
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Abstract
The present invention relates to compositions, methods, kits and systems employing irradiation activated agents to improve or increase or prevent loss of toughness, work-to-fracture, post-yield toughness, fracture toughness and/or fatigue strength of a bone allograft on exposure to radiation. The irradiation activated agent can be an agent that increases crosslinking of collagen in bone during irradiation, for example ribose, 2-hydroxytetrahydropyran or ascorbate.
Claims15
A method for processing a bone allograft comprising (a) treating the bone allograft with an effective amount of an irradiation activated agent to improve, restore, protect, increase or prevent or minimize loss of, toughness, post-yield toughness, work-to-fracture, fracture toughness and/or fatigue strength on exposure of the bone allograft to radiation;
- (b) irradiating the bone allograft;
- and (c) optionally inactivating the agent.
A method for increasing the toughness, post-yield toughness, work-to-fracture, fracture toughness and/or fatigue strength of irradiated bone allografts comprising irradiating the bone allografts in the presence of an effective amount of an irradiation activated agent, wherein the irradiation activated agent is ribose, ascorbate or 2-hydroxytetrahydropyran.
A method of providing a bone allograft for use in a medical procedure comprising introducing a bone allograft in a container having disposed therein a composition comprising an irradiation activated agent, wherein the irradiation activated agent is in an amount effective to improve, or prevent or minimize loss of toughness, work-to-fracture, fracture toughness and/or fatigue strength on exposure of the bone allograft to radiation.
Dependencies are inferred from the claim text.