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AssigneeBayer Intellectual Property GmbH
InventorsThomas LANGGUTH, Stefan BRACHT, Michael DITTGEN, Petra HUBER, Dirk SCHENK
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The present invention relates to a patch comprising a drug-containing layer with low content of hormones, such as gestodene, and optionally an estrogen (e.g. ethinyl estradiol). Upon administering the patch to a woman, plasma levels of at least 1.0 ng/ml of Gestodene is achieved at steady state conditions without the need of incorporating penetration enhancers or permeation enhancers in the drug-containing layer. Satisfactorily plasma levels of the hormones is also achieved throughout a period of at least 1 week, making the patch applicable for being used in female contraception with the concept of administering the patch ones weekly.
-21. (canceled)
A composition for transdermal delivery comprising a drug-containing layer wherein the drug-containing layer comprises Gestodene or an ester thereof and at least one pharmaceutically acceptable carrier which comprises one or more polyisobutylene polymer(s), wherein the drug-containing layer contains 25% to 99% by weight of the polyisobutylene polymer(s), wherein the drug-containing layer has a solubility for said Gestodene or an ester thereof of no more than 3% by weight of the drug-containing layer and the Gestodene or an ester thereof is completely dissolved in the layer, wherein the Gestodene or an ester thereof is in an amount ranging between 0.5 and 3% by weight of the drug-containing layer, and wherein the drug-containing layer comprises less than 1.0% by weight of a skin penetration or permeation enhancer.
Dependencies are inferred from the claim text.