Vaccines with enhanced immune response and methods for their preparation
AssigneeImmunovaccine Technologies Inc.
InventorsRobert George Brown, Bill Pohajdak, Warwick Charles Kimmins
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Abstract
The present invention is concerned with vaccines and their preparation. An effective long-term immune response, especially in mammals, can be produced using a vaccine comprising an antigen encapsulated in liposomes, a suitable adjuvant and a carrier comprising a continuous phase of a hydrophobic substance. The vaccine is particularly effective in eliciting the production of antibodies that recognize epitopes of native proteins.
Claims21
A composition for use as a vaccine, comprising:
- (a) a carrier comprising a continuous phase of a hydrophobic substance;
- (b) liposomes;
- (c) an antigen;
- and,
- (d) an adjuvant.
A method for potentiating an immune response in an animal, which method comprises administering to the animal an effective amount of a vaccine composition comprising:
- (a) a carrier comprising a continuous phase of a hydrophobic substance;
- (b) liposomes;
- (c) an antigen;
- and,
- (d) an adjuvant.
A method of preparing a vaccine composition comprising the steps of:
- (a) encapsulating an antigen or an antigen/adjuvant complex in liposomes to form liposome-encapsulated antigen;
- (b) mixing the liposome-encapsulated antigen with a carrier comprising a continuous phase of a hydrophobic substance;
- and,
- (c) adding an adjuvant if an antigen/adjuvant complex is not used in part (a).
21-43. (canceled)
Dependencies are inferred from the claim text.