Methods of Treatment with Nitric Oxide at Pressures Greater Than One Atmosphere

A method of delivering a gas mixture containing an effective amount of nitric oxide to a treatment site of a subject comprising the steps of:

• providing a flow-controlled source of a gas mixture containing nitric oxide;
• providing a bathing unit around the skin surface of the subject, the bathing unit forming a seal with the skin surface of the subject, wherein the treatment site is at or beneath the skin surface of the subject;
• transporting the gas mixture to the bathing unit so as to bathe the treatment site of the subject with the gas mixture at a pressure greater than 1 atmosphere.