Multimodal trail molecules and uses in cellular therapies
AssigneeThe General Hospital Corporation
InventorKhalid Shah
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Abstract
Described herein are novel compositions comprising multimodal TRAIL agents and cells engineered to express such multimodal TRAIL agents, including cells encapsulated in a scaffold or matrix, for use in the treatment of disorders such as cancer.
Claims25
A multimodal TRAIL agent comprising a reporter module and a therapeutic TRAIL module, wherein said therapeutic TRAIL module comprises an extracellular domain of human TRAIL.
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A cell comprising the nucleic acid sequence encoding a multimodal TRAIL agent comprising a reporter module and a therapeutic TRAIL module, wherein said therapeutic TRAIL module comprises an extracellular domain of human TRAIL.
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A method of treating a subject having a malignant condition comprising administering a therapeutically effective amount of a pharmaceutical composition comprising a multimodal TRAIL agent comprising a reporter module and a therapeutic TRAIL module, wherein said therapeutic TRAIL module comprises an extracellular domain of human TRAIL and a pharmaceutically acceptable carrier.
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Dependencies are inferred from the claim text.