Methods of diagnosing and treating pancreatic cancer
AssigneeHadasit Medical Research Services and Development Ltd.
InventorsAaron Palmon, Omer Deutsch, Doron Aframian, Oren Lahav
Life of this patent
Estimating the term…
Abstract
A method of diagnosing pancreatic cancer in a subject is provided. The method comprising determining a level and/or activity of at least one saliva secreted marker in a saliva sample of the subject wherein an alteration in said marker with respect to an unaffected saliva sample is indicative of the pancreatic cancer.
Claims20
A method of diagnosing pancreatic cancer in a subject, the method comprising determining a level and/or activity of at least one marker in a saliva sample of the subject, said at least one marker being selected from the group consisting of myeloperoxidase precursor, protein S100-A8, transthyretin precursor, lipocalin-1 precursor, transketolase and keratin type I cytoskeletal 10, wherein an alteration in said marker with respect to an unaffected saliva sample is indicative of the pancreatic cancer.
2-5. (canceled)
A method of monitoring treatment efficacy of a pancreatic cancer in a subject in need thereof, the method comprising:
- (a) treating the subject against said pancreatic cancer;
- and
- (b) determining a level and/or activity of at least one marker in a saliva sample of the treated subject, said at least one marker being selected from the group consisting of myeloperoxidase precursor, protein S100-A8, transthyretin precursor, lipocalin-1 precursor, transketolase and keratin type I cytoskeletal 10,
- wherein an alteration in said level and/or activity of said at least one marker with respect to same in a saliva sample taken prior to said treatment, rendering said level and/or activity more similar to that in an unaffected sample, is indicative of an efficacious treatment.
9-10. (canceled)
A kit for diagnosing pancreatic cancer in a subject, the kit comprising a packaging material which comprises at least one agent which specifically determines a level and/or activity of at least one marker selected from the group consisting of myeloperoxidase precursor, protein S100-A8, transthyretin precursor, lipocalin-1 precursor, transketolase, keratin type I cytoskeletal 10, Histone H4, basic salivary proline-rich protein precursor, histone H2B type 1-A, apolipoprotein A-I precursor, short palate lung, nasal epithelium carcinoma-associated protein 2 precursor, alpha-2-macroglobulin precursor, small proline-rich protein 2A, azurocidin precursor, histone H2B type 1-B, 6-phosphogluconate dehydrogenase decarboxylating, alpha-amylase 1 precursor, hemoglobin subunit alpha and hemoglobin subunit delta, in a saliva sample of the subject.
(canceled)
A device for diagnosing pancreatic cancer, the device comprising a support and at least one agent for specifically determining a level and/or activity of at least one marker in a biological sample of the subject attached to said support, wherein said marker is selected from the group consisting of myeloperoxidase precursor, protein S100-A8, transthyretin precursor, lipocalin-1 precursor, transketolase, keratin type I cytoskeletal 10, Histone H4, basic salivary proline-rich protein precursor, histone H2B type 1-A, apolipoprotein A-I precursor, short palate lung, nasal epithelium carcinoma-associated protein 2 precursor, alpha-2-macroglobulin precursor, small proline-rich protein 2A, azurocidin precursor, histone H2B type 1-B, 6-phosphogluconate dehydrogenase decarboxylating, alpha-amylase 1 precursor, hemoglobin subunit alpha and hemoglobin subunit delta.
24-26. (canceled)
Dependencies are inferred from the claim text.