Back to results
US 2014/0065189 A1Published application
Adjuvant compositions and methods for enhancing immune responses to polynucleotide-based vaccines
AssigneeVical Incorporated
InventorCARL J. WHEELER
Life of this patent
Estimating the term…
Abstract
The invention provides adjuvants, immunogenic compositions, and methods useful for polynucleotide-based vaccination and immune response. In particular, the invention provides an adjuvant of cytofectin:co-lipid mixture wherein cytofectin is GAP-DMORIE.
Claims17
A method for increasing the immune response to a fungal infection in a mammal comprising administering to the mammal an immunogenic composition comprising:
- (a) one or more immunogen-encoding polynucleotides, or immunogenic polypeptides or polysaccharides from the fungus, in an amount sufficient to increase the immune response in the mammal to the polynucleotides, polypeptides, or polysaccharides;
- and
- (b) an adjuvant comprising a (±)-N-(3-aminopropyl)-N,N-dimethyl-2,3-bis(syn-9-tetradeceneyloxy)-1-propanaminium salt and one or more co-lipids, wherein the immune response to the fungal infection is increased in the mammal.
Dependencies are inferred from the claim text.