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US 2014/0058126 A1Published application
New process for the preparation of 2,4,5- trifluorophenylacetic acid"
AssigneeF.I.S.—Fabrica Italiana Sintetici S.p.A.
InventorsStefano Tartaggia, Andrea Caporale, Ottorino De Lucchi
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Abstract
The present invention relates to a new process for the preparation of 2,4,5-trifluorophenylacetic acid and salts thereof by means of new synthetic intermediates.
Claims17
Process for the preparation of 2,4,5-trifluorophenylacetic acid of formula (I) or a salt thereof:
- comprising the following steps:
- (a) halogenation of the compound of formula (VII):
- in which X is a halogen atom,
- to give the compound of formula (V):
- in which X and X′ are independently halogen atoms,
- and/or the compound of formula (VI):
- in which X and X′ are independently halogen atoms,
- (b) dehydrohalogenation of the compound/s obtained in the previous step to give the compound of formula (IV):
- in which X is a halogen atom;
- (c) conversion of the compound obtained in the previous step into the compound of formula (II):
- in which R is a linear or branched C1-C5 alkyl or is an aryl or benzyl group;
- and/or into the compound of formula (III):
- in which X is a halogen atom and R is a linear or branched C1-C5 alkyl or is an aryl or benzyl group;
- (d) hydrolysis of the compound/s obtained in the previous step to give the compound of formula (I) or salts thereof:
- or, alternatively to the steps (c) and (d) the following step:
- (e) direct hydrolysis of the compound of formula (IV) obtained in the step (b) to give the compound of formula (I) or salts thereof.
13 more elements
The following compounds:
- intermediate of formula (II)
- in which R is a linear or branched C3-C5 alkyl or is an aryl or benzyl group;
- intermediate of formula (III)
- in which X is a halogen atom and R is a linear or branched C1-C5 alkyl or is an aryl or benzyl group;
- intermediate of formula (IV):
- in which X is a halogen atom;
- intermediate of formula (V):
- in which X and X′ are independently halogen atoms,
- intermediate of formula (VI):
- in which X and X′ are independently halogen atoms,
- intermediate of formula (VII):
- in which X is Fluorine or Iodine.
9 more elements
Dependencies are inferred from the claim text.