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US 2014/0051840 A1Published application
Arsenic complexes for potential diagnostic applications
AssigneeThe Curators of the University of Missouri
InventorsSilvia S. Jurisson, Cathy S. Cutler, Donald E. Wycoff, Anthony J. DeGraffenreid
Life of this patent
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Abstract
The present invention provides radioactive arsenic complex useful in diagnostic and therapeutic applications and methods for forming those arsenic complexes.
Claims48
A composition comprising a compound of Formula (I):
- wherein arsenic is radioactive;
- R1, R2, R3, R4, and R5 are independently selected from hydrogen, hydrocarbyl, substituted hydrocarbyl, amines, substituted amines, halogens, hydroxyl, thiol, or nitro groups or are joined together to form one or more fused ring systems selected from hydrocarbyl, substituted hydrocarbyl, aromatic, and heteroaromatic rings;
- X represents ligand atoms wherein X is chosen from carbon, sulfur, and nitrogen;
- and
- X may be further substituted by hydrogen, hydrocarbyl or substituted hydrocarbyl.
2 more elements
A composition comprising Formula (II):
- wherein arsenic is radioactive;
- R1, R2, R3, R4, and R5 are independently selected from hydrogen, hydrocarbyl, substituted hydrocarbyl, amines, substituted amines, halogens, hydroxyl, thiol, or nitro groups or are joined together to form one or more fused ring systems selected from hydrocarbyl, substituted hydrocarbyl, aromatic and heteroaromatic rings;
- and
- R6, R7, R8, and R9 are independently selected from hydrogen, hydrocarbyl, substituted hydrocarbyl, amines, substituted amines, halogens, hydroxyl, thiol, or nitro groups or are joined together to form one or more fused ring systems selected from hydrocarbyl and substituted hydrocarbyl rings and aromatic and heteroaromatic rings.
1 more element
A composition comprising Formula (III):
- wherein arsenic is radioactive;
- R1, R2, R3, R4, and R5 are independently selected from hydrogen, hydrocarbyl, substituted hydrocarbyl, amines, substituted amines, halogens, hydroxyl, thiol, or nitro groups or are joined together to form one or more fused ring systems selected from hydrocarbyl, substituted hydrocarbyl rings, aromatic and heteroaromatic rings;
- and
- R6, R7, R8, R9, R10, and R11 are independently selected from hydrogen, hydrocarbyl, substituted hydrocarbyl, amines, substituted amines, halogens, hydroxyl, thiol, or nitro groups or are joined together to form one or more fused ring systems selected from hydrocarbyl, substituted hydrocarbyl, aromatic and heteroaromatic rings.
1 more element
A radiopharmaceutical comprising Formula (I), (II), or (III):
- wherein arsenic is radioactive;
- X represents ligand atoms wherein X is chosen from carbon, sulfur, and nitrogen;
- X may be further substituted with hydrogen, hydrocarbyl or substituted hydrocarbyl;
- R1, R2, R3, R4, and R5 are independently selected from hydrogen, hydrocarbyl, substituted hydrocarbyl, amines, substituted amines, halogens, hydroxyl, thiol, or nitro groups or are joined together to form one or more fused ring systems selected from hydrocarbyl, substituted hydrocarbyl, aromatic and heteroaromatic rings;
- and
- R6, R7, R8, R9, R10, and R11 are independently selected from hydrogen, hydrocarbyl, substituted hydrocarbyl, amines, substituted amines, halogens, hydroxyl, thiol, or nitro groups or are joined together to form one or more fused ring systems selected from hydrocarbyl and substituted hydrocarbyl rings and aromatic and heteroaromatic rings.
3 more elements
A method of producing radiolabeled phenylarsonic acid, the method comprising:
- (a) contacting a radiolabeled arsenous acid with a carbonate to form a first solution;
- (b) optionally contacting the first solution with a copper-based catalyst to form a second solution;
- and
- (c) contacting the second solution with a phenyldiazonium salt to give a third solution comprising the radiolabeled phenylarsonic acid.
1 more element
Dependencies are inferred from the claim text.