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AssigneeUniversity of Rochester
InventorsYuhchyau CHEN, J.H. David WU, Jane L. LIESVELD, Lin GAN
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Disclosed are transgenic non-human mammals, which useful for the screening of thrombopoietin mimetics, thrombopoietin receptor agonists, or thrombopoietin receptor antagonists active on the human thrombopoietin receptor. The transgenic non-human mammal has a genome that comprises a stably integrated transgene construct comprising a polynucleotide sequence encoding a humanized thrombopoietin receptor wherein said transgenic non-human mammal has a baseline blood platelet count corresponding to a physiological blood platelet count of a matched non-transgenic non-human mammal. The chimeric thrombopoietin receptor comprises either the transmembrane domain of a human thrombopoietin receptor or both the extracellular and transmembrane domains of a human thrombopoietin receptor operably coupled to a cytoplasmic domain of a non-human thrombopoietin receptor.
A transgenic non-human mammal whose genome comprises a stably integrated transgene construct comprising a polynucleotide sequence encoding a humanized thrombopoietin receptor wherein said transgenic non-human mammal has a baseline blood platelet count corresponding to a physiological blood platelet count of a matched non-transgenic non-human mammal.
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A transgenic non-human mammal whose genome comprises a stably integrated transgene construct comprising a polynucleotide sequence encoding a chimeric thrombopoietin receptor, wherein the chimeric thrombopoietin receptor comprises extracellular and transmembrane domains of a human thrombopoietin receptor operably coupled to a cytoplasmic domain of a non-human thrombopoietin receptor.
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A method of treating a subject for acute radiation syndrome comprising:
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A method of treating a subject for chronic radiation syndrome comprising:
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A method of treating a subject having a bone marrow injury resulting from exposure to a non-therapeutic chemical agent comprising:
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A method inducing tissue repair or tissue regeneration in a subject comprising:
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Dependencies are inferred from the claim text.