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US 2014/0045799 A1Published application
Inositol hexakisphosphate analogs and uses thereof
AssigneeBoard of Regents, The University of Texas System
InventorsTor C. Savidge, Petril Urvil, Dhananjaya Nauduri, Numan Oezguen, Catherine Schein, Werner Braun
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Abstract
Provided herein are analog and derivative compounds of inositol hexakisphosphate effective to treat a Clostridium difficile infection and to neutralize the bacterial toxins produced by the same. In addition, methods of treating the C. difficile infection and for neutralizing its toxins with the compounds are provided.
Claims22
-20. (canceled)
A method for neutralizing a Clostridium difficile bacterial toxin, comprising contacting the C. difficile bacterial toxin with
- an inositol hexakisphosphate analog having a chemical structure of Formula I:
- wherein R1, R2, R3, R4, R5, and R6 independently are —PO(OH)2, —PS(OH)2, —PSe(OH)2, or —AsO3;
- at least one of R1, R2, R3, R4, R5, and R6 is —PS(OH)2, —PSe(OH)2, or —AsO3;
- and R1 and R3 are not both —PS(OH)2 or —PSe(OH)2 when R2, R4, R5, and R6 are —PO(OH)2.
1 more element
(canceled)
Dependencies are inferred from the claim text.