Metabolic engineering of plants for increased homogentisate and tocochromanol production
AssigneeThe Curators of the University of Missouri
InventorsGARY STACEY, MINVILUZ G. STACEY
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Abstract
The invention provides methods and compositions for modifying tocochromanol biosynthesis in plants. The present invention thus surprisingly and beneficially provides for increasing desired tocochromanol compounds in plants and enhancing the nutritional quality of human food and animal feed, without associate deleterious plant phenotypes.
Claims31
A plant comprising down-regulated homogentisic acid dioxygenase (HGO), the plant comprising increased homogentisic acid (HGA) or a metabolic product derived therefrom as a result of the down-regulated HGO relative to a wild-type plant, and wherein the plant lacks deleterious morphological traits relative to a wild type plant.
A method of increasing production of homogentisic acid (HGA) or a metabolic product derived therefrom in a plant comprising down-regulating homogentisic acid dioxygenase (HGO) in the plant relative to a wild-type plant, wherein the plant lacks deleterious morphological traits relative to a wild type plant.
A method of increasing tolerance to an herbicidal inhibitor of ρ-hydroxyphenylpyruvate dioxygenase (HPPD) in a plant comprising down-regulating homogentisic acid dioxygenase (HGO) in the plant relative to a wild-type plant, wherein the plant comprises increased tolerance to an herbicidal inhibitor of ρ-hydroxyphenylpyruvate dioxygenase (HPPD) and lacks deleterious morphological traits relative to a wild type plant.
Dependencies are inferred from the claim text.