Degradable thiol-ene polymers
AssigneeThe Regents of the University of Colorado, a body corporate
InventorsChristopher BOWMAN, Kristi ANSETH, Bilge HACIOGLU, Charlie NUTTELMAN
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Abstract
A thiol-ene polymeric material is disclosed. The material is produced by the photopolymerization of reactants having thiol and olefin moieties. The material can incorporate encapsulated components, including cells. Additionally, the material can be derivatized by reacting the polymeric material with components such as proteins.
Claims15
A method for producing a biocompatible cross-linked degradable thiol-ene hydrogel polymer comprising subjecting a polymerization reaction mixture comprising a thiol compound and an olefin compound to a radical polymerization reaction under conditions sufficient to produce a biocompatible cross-linked degradable thiol-ene hydrogel polymer, wherein the thiol compound comprises m number of reactive thiol groups, and the olefin compound comprises n number of reactive ene groups, and wherein each of n and m is an integer of at least 2, provided the sum of n+m is at least 5.
A biocompatible cross-linked degradable thiol-ene hydrogel polymer of the formula:
- —[—S—R1—S—C—C—R2—C—C—]— I
- wherein R1 and R2 are independent linkers, and at least one of R1 and R2 is degradable, and
- wherein at least one of R1 and R2 comprises a cross-linking moiety;
- and wherein each of R1 and R2 independently comprises a polymeric moiety selected from the group consisting of poly(lactic acid) (PLA);
- polyglycolide (PGA);
- a copolymer of PLA and PGA (PLGA);
- poly(vinyl alcohol) (PVA);
- poly(ethylene glycol) (PEG);
- poly(ethylene oxide);
- a poly(ethylene oxide)-co-poly(propylene oxide) block copolymer;
- a poloxarnine;
- a polyanhydride;
- a polyorthoester;
- a poly(hydroxy acids);
- a polydioxanone;
- a polycarbonate;
- a polyaminocarbonate;
- a poly(vinyl pyrrolidone);
- a poly(ethyl oxazoline);
- a carboxymethyl cellulose;
- a hydroxyalkylated cellulose;
- a polypeptide;
- a polysaccharide;
- a carbohydrate;
- heparan sulfate;
- chondroitin sulfate;
- heparin, alginate;
- and a combination thereof,
- and wherein each of the —C—C— portion of Formula I is derived from an olefinic portion of a vinyl moiety, a vinyl acetyl moiety, a vinyl ether moiety, an allyl moiety, an acrylate moiety, a methacrylate moiety, a maleimide moiety, or a norbornene moiety.
Dependencies are inferred from the claim text.