System for Targeted Delivery of Therapeutic Agents
AssigneesThe Brigham and Women's Hospital, Inc., Massachusetts Institute of Technology
InventorsJianjun Cheng, Omid C. Farokhzad, Robert S. Langer, Benjamin A. Teply, Stephen E. Zale
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Abstract
The present invention provides a drug delivery system for targeted delivery of therapeutic agent-containing particles to tissues, cells, and intracellular compartments. The invention provides targeted particles comprising a particle, one or more targeting moieties, and one or more therapeutic agents to be delivered and pharmaceutical compositions comprising inventive targeted particles. The present invention provides methods of designing, manufacturing, and using inventive targeted particles and pharmaceutical compositions thereof.
Claims18
1-105. (canceled)
A targeted particle comprising a polymer conjugated to a surfactant, hydrophilic polymer or lipid,
- the particle having bound thereto a plurality of protein or small molecule targeting moieties that specifically bind to prostate specific membrane antigen (PSMA), and
- having encapsulated or dispersed therein a taxane,
- wherein at least 80% of the particles have a greatest dimension less than 250 nm and have enhanced permeation through tumor vasculature and retention in tumor tissue as compared to particles greater than 250 nm.
A method of treating cancer in a subject, comprising administering an effective amount of a targeted particle comprising a polymer conjugated to a surfactant, hydrophilic polymer or lipid,
- the particle having bound thereto a plurality of protein or small molecule targeting moieties that specifically bind to prostate specific membrane antigen (PSMA), and
- having encapsulated or dispersed therein a taxane,
- wherein at least 80% of the particles have a greatest dimension less than 250 nm and have enhanced permeation through tumor vasculature and retention in tumor tissue as compared to particles greater than 250 nm.
Dependencies are inferred from the claim text.