Methods of and compositions for inhibiting the proliferation of mammalian cells
AssigneeYissum Research Development Company of the Hebrew University of Jerusalem
InventorsLevava ROIZ, Betty Schwartz, Patricia Smirnoff, Oded Shoseyov
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Abstract
A method of preventing, inhibiting and/or reversing cell motility, actin filament assembly or disassembly, proliferation, colonization, differentiation, accumulation and/or development of abnormal cells in a subject is disclosed. The method is effected by administering to the subject a therapeutically effective amount of a ribonuclease of the T2 family having actin binding activity.
Claims13
A method of preventing or treating a disease or condition selected from the group consisting of a proliferative disorder, inflammatory disease or condition and ischemic disease or condition in a subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of a ribonuclease of the T2 family wherein the ribonuclease T2 binds actin in either its active or non-active ribonucleolytic form.
Dependencies are inferred from the claim text.