Generating epigenentic cohorts through clustering of epigenetic suprisal data based on parameters

A computer program product for generating epigenetic cohorts for a specific time period through clustering of epigenetic surprisal data at a specific time comprising:

• one or more computer-readable, tangible storage devices;
• program instructions, stored on at least one of the one or more storage devices, to receive a phenotypic and/or demographic parameter and a cluster characteristics input from a user;
• program instructions, stored on at least one of the one or more storage devices, to search the epigenetic surprisal data at a specific time associated with a patient for the phenotypic and/or demographic parameter and store matches of the parameter with the epigenetic surprisal data in a repository;
• program instructions, stored on at least one of the one or more storage devices, to generate a cluster comprising a centroid for each parameter by populating the cluster based on the matches of the parameter with the epigenetic surprisal data at a specific time period;
• program instructions, stored on at least one of the one or more storage devices, to determine at least two epigenetic cohorts for a specific time period, a control cohort and a treatment cohort, from the cluster for each parameter and based on the input from the user;
• and
• if the cohorts do not match the input of the user, program instructions, stored on at least one of the one or more storage devices, to report the cohorts determined to the user and return to program instructions, stored on at least one of the one or more storage devices, to receive a phenotypic and/or demographic parameter from a user and a cluster characteristics input.

A system for generating epigenetic cohorts for a specific time period through clustering of epigenetic surprisal data at a specific time comprising:

• one or more processors, one or more computer-readable memories and one or more computer-readable, tangible storage devices;
• program instructions, stored on at least one of the one or more storage devices for execution by at least one of the one or more processors via at least one of the one or more memories, to receive a phenotypic and/or demographic parameter and a cluster characteristics input from a user;
• program instructions, stored on at least one of the one or more storage devices for execution by at least one of the one or more processors via at least one of the one or more memories, to search the epigenetic surprisal data at a specific time associated with a patient for the phenotypic and/or demographic parameter and store matches of the parameter with the epigenetic surprisal data in a repository;
• program instructions, stored on at least one of the one or more storage devices for execution by at least one of the one or more processors via at least one of the one or more memories, to generate a cluster comprising a centroid for each parameter by populating the cluster based on the matches of the parameter with the epigenetic surprisal data at a specific time period;
• program instructions, stored on at least one of the one or more storage devices for execution by at least one of the one or more processors via at least one of the one or more memories, to determine at least two epigenetic cohorts for a specific time period, a control cohort and a treatment cohort, from the cluster for each parameter and based on the input from the user;
• and
• if the cohorts do not match the input of the user, program instructions, stored on at least one of the one or more storage devices for execution by at least one of the one or more processors via at least one of the one or more memories, to report the cohorts determined to the user and return to program instructions, stored on at least one of the one or more storage devices, to receive a phenotypic and/or demographic parameter from a user and a cluster characteristics input.