Devices and methods for predicting and preventing restenosis

A system for indicating an enhanced risk of restenosis in an arterial tissue, the system comprising:

• an imaging modality configured to image a region of arterial tissue;
• and
• a processor configured to receive the image of the region of arterial tissue from the imaging modality and to determine a measure of hypercellularity and further configured to determine one or both of:
• a measure of how lipid-rich the tissue region is and a measure of how many inflammatory cells there are associated with the tissue region;
• and
• index logic configured to determine an index of restenosis for the tissue region based on the measure of hypercellularlity and one or both of the measures of how lipid-rich the first tissue region is and the measure of how many inflammatory cells are associated with the first tissue region.

A method of determining an enhanced risk of restenosis in an arterial tissue, the method comprising:

• determining a measure of hypercellularity in a first arterial tissue region;
• determining one or both of:
• a measure of how lipid-rich the first tissue region is and a measure of how many inflammatory cells there are associated with the first tissue region;
• determining an index of restenosis for the first tissue region based on the measure of hypercellularlity and one or both of the measures of how lipid-rich the first tissue region is and the measure of how many inflammatory cells are associated with the first tissue region;
• and
• presenting the index of restenosis for the first tissue region.