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US 2014/0005420 A1Published application
Salts and Polymorphs of a Tetracycline Compound
AssigneeParatek Pharmaceuticals, Inc.
InventorsRaymond Cvetovich, Tadeusz Warchol
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Abstract
Crystalline forms, including salts and polymorphs, of a compound useful in the treatment of tetracycline compound-responsive states are provided herein. The crystalline compounds are useful for the treatment or prevention of conditions and disorders such as bacterial infections and neoplasms, as well as other known applications for tetracycline compounds in general.
Claims20
A method of preparing a stable crystalline tosylate salt of Compound 1:
- wherein the method comprises:
- dissolving a freebase of Compound 1 in a first solvent or combination of solvents to form a first solution;
- dissolving p-toluenesulfonic acid in a second solvent or combination of solvents to form a second solution;
- combining the first and second solution to form a third solution;
- and
- adding a polymorph of a tosylate salt of Compound 1 to the third solution to form a fourth solution.
3 more elements
Dependencies are inferred from the claim text.