Process for producing thiophene compound and intermediate thereof
AssigneeNissan Chemical Industries, Ltd.
InventorsKazufumi YANAGIHARA, Shingo UMEZAWA, Katsuaki MIYAJI
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AssigneeNissan Chemical Industries, Ltd.
InventorsKazufumi YANAGIHARA, Shingo UMEZAWA, Katsuaki MIYAJI
Estimating the term…
To provide a novel process for producing a 2-aryl-3-hydroxy-4-substituted carbonyl thiophene compound or an intermediate thereof useful as an intermediate for production of medicines and agricultural chemicals. A 2-aryl acetate compound represented by the formula (1): wherein R1 is an aryl group or the like, R4 is a C1-3 alkyl group or the like, and X is a leaving group, is reacted with a thioacetic acid compound to form a thioacetyl compound (3), the thioacetyl compound (3) is reacted with a vinyl ketone compound to form a γ-ketosulfide compound (5), which is cyclized under basic conditions to form a dihydrothiophene compound (6), and the dihydrothiophene compound (6) is oxidized by using an oxidizing agent to produce a 2-aryl-3-hydroxy-4-substituted carbonyl thiophene compound (7).
1-10. (canceled)
A dihydrothiophene compound represented by the formula (6):
A dihydrothiophene compound represented by any one of the following formulae:
Dependencies are inferred from the claim text.