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US 2014/0005398 A1Published application
Borate moiety-contained linker and bio-sensing element containing the same
AssigneeNational Chiao Tung University
InventorsYaw-Kuen LI, Mo-Yuan SHEN, Yu-Ju PIEN
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Abstract
A borate moiety-contained linker and a bio-sensing element containing the same are disclosed. The borate moiety-contained linker can be used to modify a sensing molecule and connect the sensing molecule to a substrate to form the bio-sensing element.
Claims25
A borate moiety-contained linker for modifying a sensing molecule and connecting the sensing molecule to a substrate, the linker comprising a compound having a structure represented by the following chemical formula (I):
- wherein
- R1 is one of the following chemical structures:
- L, X and Z are independently selected from the group consisting of amide bond (—CONH— and —NHCO—), ester bond (—COO— and —OCO—), 1,3-succinimide bond
- and triazole bond
- and X, Z and L are different to each other,
- Y is thiol group (—SH), amine group (—NH2), azido group (—N3), carboxylic acid group (—COOH) or disulfide-contained group (—S—S—R2),
- R2 is pyridine
- or 1,2-dithiolane-contained group
- R3 is methylene group (—CH2—) or N-(3H-1,2,3,-triazo)-4-methyl pentanamide
- R4 is hydrogen (H) or nitro group (—NO2),
- m is an integral from 1 to 10,
- n is an integral from 0 to 10, and
- o is 1 or 2.
10 more elements
Dependencies are inferred from the claim text.