Nitrogen-containing condensed heterocyclic compound

A compound represented by the following general formula (I) or a pharmaceutically acceptable salt thereof:

• wherein
• Ring A represents a partially saturated heteroaryl group which may be substituted by 1 or 2 substituents, which may be the same or different, selected from the group consisting of:
• a C1-8 alkyl group, and
• an oxo group,
• an aryl group or a heteroaryl group, which aryl group and heteroaryl group may be each substituted by 1 to 3 substituents, which may be the same or different, selected from the group consisting of (i) to (vii) below:
• (i) a halogen atom,
• (ii) a hydroxy group,
• (iii) a C1-8 alkyl group which may be substituted by 1 to 3 substituents, which may be the same or different, selected from the group consisting of:
• a hydroxy group,
• a halogen atom,
• a C1-8 alkoxy group which may be substituted by one saturated heterocyclyl group,
• a C3-8 cycloalkyl group,
• a saturated heterocyclyl group, and
• an aryl group,
• (iv) a C1-8 alkoxy group which may be substituted by 1 to 3 substituents, which may be the same or different, selected from the group consisting of:
• (iv-1) a halogen atom,
• (iv-2) an oxo group,
• (iv-3) a C3-8 cycloalkyl group,
• (iv-4) a saturated heterocyclyl group which may be substituted by 1 or 2 substituents, which may be the same or different, selected from the group consisting of:
• a halogen atom,
• a C1-8 alkyl group, and
• an oxo group,
• (iv-5) an aryl group,
• (iv-6) a heteroaryl group,
• (iv-7) a C1-8 alkoxy group which may be substituted by 1 to 3 substituents, which may be the same or different, selected from the group consisting of:
• a halogen atom,
• a saturated heterocyclyl group, and
• a C1-8 alkoxy group,
• (iv-8) a C3-8 cycloalkyloxy group,
• (iv-9) an aryloxy group which may be substituted by one substituent selected from the group consisting of:
• a halogen atom,
• a C1-8 alkyl group which may be substituted by 1 to 3 halogen atoms, and
• a C1-8 alkoxy group,
• (iv-10) a C1-8 alkylsulfonyl group, and
• (iv-11) an arylsulfonyl group,
• (v) a C2-8 alkenyloxy group,
• (vi) a monoC1-8 alkylamino group which may be substituted by one aryl group, and
• (vii) a diC1-8 alkylamino group,
• RB represents a C4-18 alkyl group which may be substituted by 1 to 3 substituents, which may be the same or different, selected from the group consisting of:
• a halogen atom, and
• a C3-8 cycloalkyl group,
• a C3-8 cycloalkyl group,
• a partially saturated aryl group,
• an aryl group, or
• the following formula (II):
• wherein
• V represents the formula —CR11R — (wherein R11 and R12, which may be the same or different, each represent a hydrogen atom or a C1-4 alkyl group, or R11 and R12, taken together with the adjacent carbon atom, may form C3-6 cycloalkane), —CO—, —CO—O— or —CO—NH—,
• W represents a single bond or
• either a C1-3 alkylene group which may be substituted by 1 or 2 substituents, which may be the same or different, selected from the group consisting of:
• a fluorine atom,
• an amino group which may be substituted by one C1-4 alkyl group, and
• an oxo group, or
• a C1-3 alkylene group in which one carbon atom that forms the C1-3 alkylene group may form a C3-6 cycloalkane-1,1-diyl group, and
• Ring B represents a C3-8 cycloalkyl group which may be substituted by one C1-8 alkyl group, a C3-8 cycloalkenyl group which may be crosslinked with a C1-4 alkanediyl group or may be substituted by one C1-8 alkyl group,
• a partially saturated heteroaryl group which may be substituted by 1 or 2 halogen atoms,
• a saturated heterocyclyl group,
• an aryl group or a heteroaryl group, which aryl group and heteroaryl group may be each substituted by 1 to 3 substituents, which may be the same or different, selected from the group consisting of:
• (a) a halogen atom,
• (b) a hydroxy group,
• (c) a C1-8 alkyl group and a C1-8 alkoxy group, which C1-8 alkyl group and C1-8 alkoxy group may be each substituted by 1 to 4 substituents, which may be the same or different, selected from the group consisting of:
• a halogen atom,
• a hydroxy group,
• a C3-8 cycloalkyl group, and
• an aryl group,
• (d) a C3-8 cycloalkyl group,
• (e) an aryl group and a heteroaryl group, which aryl group and heteroaryl group may be each substituted by 1 or 2 substituents, which may be the same or different, selected from the group consisting of:
• a halogen atom, and
• a C1-8 alkyl group which may be substituted by 1 to 3 halogen atoms, and
• (f) a C1-8 alkylsulfonyl group,
• RC represents a hydrogen atom,
• a halogen atom,
• a C1-4 alkyl group which may be substituted by 1 to 3 halogen atoms,
• an aryl group, or
• a heteroaryl group,
• RD represents a hydrogen atom or a C1-4 alkyl group which may be substituted by 1 to 3 halogen atoms,
• Y represents a nitrogen atom or the formula N+(RF),
• RF represents a C1-4 alkyl group, and
• m and n, which may be the same or different, each represent an integer of 0 or 1, provided that the following compounds are excluded:
• 2-(4-fluorobenzoyl)-N-(thiazol-2-yl)isoindoline-5-sulfonamide,
• 2-(2-(1H-indol-1-yl)propanoyl)-N-(thiazol-2-yl)isoindoline-5-sulfonamide,
• 2-(2-(6-chloro-3,4-dihydroquinolin-1(2H)-yl)acetyl)-N-(pyrimidin-4-yl)isoindoline-5-sulfonamide,
• 2-(2-(7-chloro-1H-indol-yl)acetyl)-N-(pyrimidin-4-yl)isoindoline-5-sulfonamide,
• 2-(2-(6-chloro-3,4-dihydroquinolin-1(2H)-yl)propanoyl)-N-(1,2,4-thiadiazol-5-yl)isoindoline-5-sulfonamide,
• (R)—N-(6-chloropyridazin-3-yl)-2-(2-(4-fluoro-1H-indol-1-yl)propanoyl)isoindoline-5-sulfonamide,
• (R)-2-(2-(4-fluoro-1H-indol-1-yl)propanoyl)-N-(1,2,4-thiadiazol-5-yl)isoindoline-5-sulfonamide,
• (S)-2-(2-(6-chloro-3,4-dihydroquinolin-1(2H)-yl)propanoyl)-N-(5-methyl-1,3,4-thiadiazol-2-yl)isoindoline-5-sulfonamide,
• (R)—N-(5-ethyl-1,3,4-thiadiazol-2-yl)-2-(2-(4-fluoro-1H-indol-yl)propanoyl)isoindoline-5-sulfonamide,
• 2-(2-(6-chloro-3,4-dihydroquinolin-1(2H)-yl)acetyl)-N-(1,2,4-thiadiazol-5-yl)isoindoline-5-sulfonamide,
• (S)-2-(2-(4-fluoro-1H-indol-1-yl)propanoyl)-N-(1,2,4-thiadiazol-5-yl)isoindoline-5-sulfonamide,
• 2-(3-(5-chloro-1H-indol-1-yl)propanoyl)-N-(1,2,4-thiadiazol-5-yl)isoindoline-5-sulfonamide,
• 2-(2-(6-chloro-3,4-dihydroquinolin-1(2H)-yl)propanoyl)-N-(5-ethyl-1,3,4-thiadiazol-2-yl)isoindoline-5-sulfonamide,
• (S)-2-(2-(6-chloro-3,4-dihydroquinolin-1(2H)-yl)propanoyl)-N-(6-chloropyridazin-3-yl)isoindoline-5-sulfonamide,
• (S)-2-(2-(1H-indol-1-yl)propanoyl)-N-(1,2,4-thiadiazol-5-yl)isoindoline-5-sulfonamide,
• 2-(3-(5-chloro-1H-indol-1-yl)propanoyl)-N-(thiazol-2-yl)isoindoline-5-sulfonamide,
• 2-(2-(4-methoxyphenyl)acetyl)-N-(thiazol-2-yl)isoindoline-5-sulfonamide,
• (S)-2-(2-(4-fluoro-1H-indol-1-yl)propanoyl)-N-(pyrimidin-4-yl)isoindoline-5-sulfonamide,
• (R)-2-(2-(1H-indol-1-yl)propanoyl)-N-(1,2,4-thiadiazol-5-yl)isoindoline-5-sulfonamide,
• 2-(2-(7-chloro-1H-indol-1-yl)acetyl)-N-(thiazol-2-yl)-1,2,3,4-tetrahydroisoquinoline-7-sulfonamide,
• 2-(2,4-difluorobenzoyl)-N-(thiazol-2-yl)-1,2,3,4-tetrahydroisoquinoline-7-sulfonamide,
• 2-(2,5-difluorobenzoyl)-N-(thiazol-2-yl)-1,2,3,4-tetrahydroisoquinoline-7-sulfonamide,
• 2-(4-fluorobenzoyl)-N-(thiazol-2-yl)-1,2,3,4-tetrahydroisoquinoline-7-sulfonamide,
• 2-(3-(5-chloro-1H-indol-1-yl)propanoyl)-N-(thiazol-2-yl)-1,2,3,4-tetrahydroisoquinoline-7-sulfonamide,
• 2-(2-fluorobenzoyl)-N-(thiazol-2-yl)-1,2,3,4-tetrahydroisoquinoline-7-sulfonamide,
• 2-(2,4-dichlorobenzoyl)-N-(thiazol-2-yl)-1,2,3,4-tetrahydroisoquinoline-7-sulfonamide, and
• 2-(4-methoxybenzoyl)-N-(thiazol-2-yl)-1,2,3,4-tetrahydroisoquinoline-7-sulfonamide.