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US 2014/0005380 A1Published application
High-purity large-scale preparation of stannsoporfin
AssigneeInfacare Pharmaceutical Corporation
InventorsGeorge S. DRUMMOND, Robert CAROSELLI, Keith A. COOKE, Daniel LEVIN, David G. ROE, Christopher P. BOUCHER
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Abstract
Large scale (bulk) compositions comprising high-purity stannsoporfin are disclosed, as well as methods of synthesizing such compositions.
Claims32
A composition comprising stannsoporfin in an amount of at least about 10 grams, wherein said stannsoporfin is at least about 98.5% pure and where any individual impurity present is present in an amount of less than about 0.1%.
A method of making stannsoporfin, comprising:
- a) exposing a metallic hydrogenation catalyst to a hydrogen atmosphere to form pre-hydrogenated catalyst;
- and
- b) contacting hernia with the pre-hydrogenated catalyst and maintaining the hemin and catalyst under one or more combinations of temperature, hydrogen pressure, and time sufficient to remove iron from the hemin and reduce the vinyl groups of the hernia to ethyl groups, thus forming mesoporphyrin IX.
A method for producing a tin (IV) porphyrin compound or salt thereof comprising:
- a) preparing a solution or suspension of an unmetallated porphyrin compound or a salt thereof;
- b) preparing a solution or suspension of tin (II) oxide, wherein steps (a) and (b) can occur in any order or simultaneously;
- and
- c) contacting the solution or suspension of tin (II) oxide with the solution or suspension of unmetallated porphyrin compound or salt thereof under conditions suitable to form the tin (IV) porphyrin compound or salt thereof.
1 more element
Dependencies are inferred from the claim text.