Recombinant cytotoxin as well as a method of producing it
AssigneeBioinfobank Sp. Z O. O.
InventorsAnna Bujko, Magdalena Lukasiak, Jaroslaw Dastych, Miroslawa Skupinska, Ewelina Rodakowska, Leszek Rychlewski
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Abstract
The subject of the present invention is a method of modifying proteinaceous toxins through the addition of an NLS motif. The resulting cytotoxin facilitates the selective elimination of proliferating cells, particularly tumour cells.
Claims11
A method of producing a recombinant cytotoxin, the method comprising adding an NLS motif to the amino-acid sequence of a known protein toxin or its derivative, wherein the result is a recombinant cytotoxin with a decreased overall cytotoxicity in comparison to the cytotoxicity of the known protein toxin or its derivative.
A fusion protein comprising an amino-acid sequence of a protein toxin and a human NLS motif amino acid sequence.
Dependencies are inferred from the claim text.