Natriuretic polypeptides
AssigneeMayo Foundation for Medical Education and Research
InventorsCandace Y.W. Lee, John C. Burnett, Jr.
Life of this patent
Estimating the term…
Abstract
This document provides methods and materials related to natriuretic polypeptides and the use of natriuretic polypeptides to treat cardiovascular and/or renal conditions. For example, chimeric polypeptides having at least one amino acid segment (e.g., N-terminus tail, ring structure, C-terminus tail, or a combination thereof) of a natriuretic peptide (e.g., ANP, BNP, CNP, URO, or DNP) and an amino acid segment of an angiotensin polypeptide (e.g., Ang-(1-7)) are provided.
Claims13
1-36. (canceled)
A polypeptide from 17 to 50 amino acid residues in length, wherein said polypeptide comprises, in an order from amino terminus to carboxy terminus:
- (a) the sequence set forth in SEQ ID NO:1 or the sequence set forth in SEQ ID NO:1 with no more than two additions, subtractions, or substitutions,
- (b) the sequence set forth in SEQ ID NO:5 or the sequence set forth in SEQ ID NO:5 with no more than five additions, subtractions, or substitutions, and
- (c) the sequence set forth in SEQ ID NO:13 or the sequence set forth in SEQ ID NO:13 with no more than two additions, subtractions, or substitutions.
43-109. (canceled)
Dependencies are inferred from the claim text.