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US 2014/0005355 A1Published application
Process for preparation of caspofungin acetate and intermediates
AssigneeBiocon Limited
InventorsKiran Kumar Kothakonda, Sandeep Rao Sripathi, Srinivas Pullela Venkata, Lijo George, Anegondi Sreenivasa Prasad
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Abstract
The present invention discloses a process for the preparation of Caspofungin and its intermediates from Pneumocandin B0.
Claims25
A process preparation of Caspofungin;
- said process comprising acts of:
- (i) conversion of pneumocandin B0 to compound of formula II in a suitable solvent,
- (ii) conversion of formula II to III in a suitable solvent,
- (iii) conversion of formula III to formula IV in a suitable solvent,
- Where Z is NHBOC or N3
- (iv) Optionally reacting compound IV with BOC deprotecting reagent in a suitable solvent to isolate Caspofungin salt wherein Z is NHBOC
- (v) Optionally hydrogenating compound of formula IV in a suitable solvent to isolating the caspofungin salt wherein Z is N3.
4 more elements
A compound of formula II,
- Wherein, R=any side chain consisting of heteroatom.
- A compound of formula III,
- Wherein, R is any side chain consisting of heteroatom.
A compound of formula IV,
- Wherein, Z═NHBOC or N3.
Dependencies are inferred from the claim text.