Compositions comprising substituted phenols and topical application thereof

A composition comprising:

• a substituted phenol of Formula II:
• wherein:
• R1 is H, OR5, amide, aminoalkyl, or aminoaryl;
• R2 is H or OR5;
• R3 is H, OR5, aminoalkyl, aminoaryl, carboxylic acid, ester, or amide;
• R4 is H, OH, C1-C3 alkylcarboxylic acid, ester or amide;
• and
• R5 is H, C1-C5 alkyl, C1-C5 acyl, or C1-C5 alkylaryl;
• or a cosmetically acceptable salt thereof;
• and
• a cosmetically acceptable topical carrier comprising an ingredient selected from the group consisting of wetting agents, emulsifiers, emollients, humectants, and fragrances.

A method of treating human skin, comprising topically applying to said human skin a composition comprising

• a substituted phenol of Formula I:
• wherein:
• A is C3-C6 alkyl, C3-C6 alkenyl, or C3-C6 alkynyl;
• R1 is H, C1-C5 alkyl, or aryl;
• R2 is H, OH, carboxylic acid, COOR4, or CONR4;
• R3 is H, C(═O)R4, COOR4, or CH2R4;
• and
• R4 is C1-C2 alkyl, C1-C2 alkenyl, C1-C2 alkylaryl;
• or a cosmetically acceptable salt thereof;
• and
• a cosmetically acceptable topical carrier comprising an ingredient selected from the group consisting of wetting agents, emulsifiers, emollients, humectants, and fragrances.

A method of treating human skin, comprising topically applying to said human skin a composition comprising

• a substituted phenol of Formula II:
• wherein:
• R1 is H, OR5, amide, aminoalkyl, or aminoaryl;
• R2 is H or OR5;
• R3 is H, OR5, aminoalkyl, aminoaryl, carboxylic acid, ester, or amide;
• R4 is H, OH, C1-C3 alkylcarboxylic acid, ester or amide;
• and
• R5 is H, C1-C5 alkyl, C1-C5 acyl, or C1-C5 alkylaryl;
• or a cosmetically acceptable salt thereof;
• and
• a cosmetically acceptable topical carrier comprising an ingredient selected from the group consisting of wetting agents, emulsifiers, emollients, humectants, and fragrances.