Delivery of Therapeutic Agents Using Oligonucleotide-Modified Nanoparticles as Carriers
AssigneeNorthwestern University
InventorsChad A. Mirkin, David A. Giljohann, Weston L. Daniel
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Abstract
Disclosed are drug delivery compositions comprising an oligonucleotide-modified nanoparticle and a therapeutic agent. Specifically, disclosed are compositions comprising a number of oligonucleotide molecules in a ratio to therapeutic agent molecules to allow a sufficient transportation of the therapeutic agent molecules into a cell. The therapeutic agents include both hydrophobic and hydrophilic. Different attachments of therapeutic agents in a composition are also described.
Claims18
A drug delivery composition comprising an oligonucleotide-modified nanoparticle and a therapeutic agent, said therapeutic agent being deliverable at a significantly lower level in the absence of attachment to the oligonucleotide-modified nanoparticle compared to the delivery of the therapeutic agent when attached to the oligonucleotide-modified nanoparticle, wherein the composition has a number of oligonucleotide molecules compared to therapeutic agent molecules in a ratio that is sufficient to allow transport of the therapeutic agent into a cell.
Dependencies are inferred from the claim text.