B- and y -diketones and y -hydroxyketones as wnt/ b -catenin signaling pathway activators

A compound or pharmaceutically acceptable salt thereof having the structure of Formula I:

• wherein R1 is an unsubstituted heteroaryl, wherein the heteroaryl is selected from the group consisting of
• with the proviso that a carbon atom of the R1 heteroaryl is attached to the carbonyl;
• R2 is a substituted or unsubstituted
• and
• R3, R4, R5 and R6 are H.

A compound or pharmaceutically acceptable salt thereof having the structure of Formula I:

• wherein R1 is an unsubstituted heteroaryl, wherein the heteroaryl is selected from the group consisting of
• with the proviso that a carbon atom of the R1 heteroaryl is attached to the carbonyl;
• R2 is an unsubstituted
• and
• R3, R4, R5 and R6 are H.

A pharmaceutical composition comprising a therapeutically effective amount of a compound or a pharmaceutically acceptable salt thereof having the structure of Formula I:

• wherein R1 is a substituted or unsubstituted heteroarvl, wherein the heteroarvl is selected from the group consisting of
• with the proviso that a carbon atom of the R1 heteroaryl is attached to the carbonyl;
• R2 is a substituted or unsubstituted
• and
• R3, R4, R5 and R6 are H;
• and a pharmaceutically acceptable excipient.