Ring-fused compound

A compound represented by

• Formula (I):
• [in the formula,
• R1 represents a lower alkyl group that may be substituted with a cycloalkyl group, a cycloalkyl group, a halo-lower alkyl group, a hydroxy-lower alkyl group, a lower alkoxy-lower alkyl group, a lower alkoxy-carbonyl group, a lower alkyl-sulfonyl group or a group represented by the general formula:
• -Q1-A1;
• Q1 represents a single bond or a lower alkylene group (herein 1 or 2, or more methylene groups constituting the lower alkylene group each independently may be substituted with a carbonyl group, a sulfinyl group or a sulfonyl group for the total methylene groups, and/or the hydrogen constituting the methylene group may be substituted with a lower alkyl group.);
• A1 represents an aryl group or a heteroaryl group, which may be substituted with one to three substituents selected from the <Substituent group L> described later (herein any two substituents adjacent to each other on the aryl group or the heteroaryl group may join together to form a lower alkylenedioxy group.);
• represents a double bond or a single bond;
• when is a double bond,
• W1 represents a nitrogen atom or a group represented by the general formula:
• ═C(Ra)—, and
• W2 represents a nitrogen atom or a group represented by the general formula:
• ═C(Rb)—;
• when is a single bond,
• W1 represents a group represented by the general formula:
• —C(Raa)(Rab)— or a group represented by the general formula:
• —(C═O)—, and
• W2 represents a group represented by the general formula:
• —C(Rba)(Rbb)—, a group represented by the general formula:
• —(C═O)— or a group represented by the general formula:
• —N(Rbc)—;
• Ra and Rb represent each independently a hydrogen atom, a substituent selected from the <Substituent group M> described later or a group represented by the general formula:
• -Q2-A2;
• Raa and Rab represent each independently a hydrogen atom, a substituent selected from the <Substituent group N> described later or a group represented by the general formula:
• -Q2-A2, or Raa and Rab may join together to form a lower alkylene group (herein 1 to 2 or more methylene groups constituting the lower alkylene group each independently may be substituted with an oxygen atom, a carbonyl group, a vinylene group or a group represented by the general formula:
• —N(Rc)— for the total methylene groups, and/or the hydrogen constituting the methylene group may be substituted with a hydroxyl group, a lower alkyl group or a halogen atom.);
• Rba and Rbb represent each independently a hydrogen atom, a halogen atom, an amino group, a lower alkyl-amino group, a di-lower alkyl-amino group, a hydroxy-lower alkyl-amino group, a lower alkyl-sulfonylamino group, a lower alkoxy-carbonylamino group, a substituent selected from the <Substituent group N> or a group represented by the general formula:
• -Q2-A2, or Rba and Rbb may join together to form a lower alkylene group (herein 1 to 2 or more methylene groups constituting the lower alkylene group each independently may be substituted with an oxygen atom, a carbonyl group, a vinylene group or a group represented by the general formula:
• —N(Rc)— for the total methylene groups, and/or the hydrogen constituting the methylene group may be substituted with a hydroxyl group, a lower alkyl group or a halogen atom.);
• Rbc represents a group selected from the group consisting of a hydrogen atom, a lower alkyl group, a cycloalkyl group, a halo-lower alkyl group, a lower alkoxy-carbonyl group, a carbamoyl group, a mono-lower alkyl-carbamoyl group, a di-lower alkyl-carbamoyl group and a lower alkanoyl group or a group represented by the general formula:
• -Q2-A2;
• Q2 represents a single bond, a lower alkylene group or a lower alkenylene group (herein 1 or 2, or more methylene groups constituting the lower alkylene group each independently may be substituted with an oxygen atom, a nitrogen atom or a carbonyl group for the total methylene groups, and/or the hydrogen constituting the methylene group may be substituted with a halogen atom, a cyano group, a hydroxyl group or a lower alkyl group.);
• A2 represents a cycloalkyl group, an aliphatic heterocyclic group, an aryl group or a heteroaryl group, which may be substituted with one to three substituents selected from the <Substituent group L> (herein any two substituents adjacent to each other on the aryl group or the heteroaryl group may join together to form a lower alkylenedioxy group.);
• W3, W4 and W5 represent each independently a nitrogen atom, or a methine group that may have a substituent selected from the group consisting of a halogen atom, a hydroxyl group, a cyano group, a lower alkyl group, a cycloalkyl group, a halo-lower alkyl group, a lower alkoxy group and a halo lower alkoxy group;
• provided that zero to four of W1, W2, W3, W4 and W5 are nitrogen atoms;
• X represents a single bond, an oxygen atom, a sulfur atom, a sulfinyl group, a sulfonyl group, a carbonyl group, a lower alkenylene group, a lower alkynylene group or a group represented by the general formula:
• —N(RX)—(herein RX is a hydrogen atom or a lower alkyl group.);
• Y is a single bond or (CRYiRYi′)n (herein n is any integer of 1 to 6, i is any integer of 1 to n, and (CRYiRYi′)n represents (CRYiRYi′) when n=1;
• represents (CRYiRYi′)—(CRY2RY2′) when n=2;
• represents (CRYiRY1′)—(CRY2RY2′)—(CRY3RY3′) when n=3;
• represents (CRY1RY1′)—(CRY2RY2′)—(CRY3RY3′)—(CRY4RY4′) when n=4;
• represents (CRY1RY1′)—(CRY2RY2′)—(CRY3RY3′)—(CRY4RY4′)—(CRY5RY5′) when n=5;
• and represents (CRY1RY1′)—(CRY2RY2′)—(CRY3RY3′)—(CRY4RY4′)—(CRY5RY5′)—(CRY6RY6′) when n=6 (herein RY1, RY′, RY2, RY2′, RY3, RY3′, RY4, RY4′, RY5, RY5′, RY6 and RY6′ are each independently a hydrogen atom, a halogen atom or a substituent selected from the <Substituent group N>,
• alternatively, in relation to RX, RY1, RY1′, RY2, RY2′, RY3, RY3′, RY4, RY4′, RY5, RY5′, RY6 and RY6′, the combinations of the two groups below:
• “RY1 and RY1′”, “RY2 and RY2′”, “RY3 and RY3′”, “RY4 and RY4′”, “RY5 and RY5′”, “RY6 and RY6′, “RX and RY1, “RX and RY2”, “RX and RY3”, “RY1 and RY2, “RY1 and RY3”, “RY and RY4”, “RY2 and RY3”, “RY2 and RY4” or “RY2 and RY5”, i.e., the two groups constituting the combinations may join together to form a lower alkylene group, wherein 1 or 2, or more methylene groups constituting the lower alkylene group each independently may be substituted with an oxygen atom, a carbonyl group, a vinylene group or a general formula:
• —N(Rc)— for the total methylene groups, and/or the hydrogen constituting the methylene group may be substituted with a hydroxyl group, a lower alkyl group or a halogen atom.);
• Rc represents a hydrogen atom, a lower alkyl group, a halo-lower alkyl group or a lower alkanoyl group;
• Z represents a hydroxyl group, COOR2, CONR3R4, SO3 R2, SO3 NR3R4, a 5-tetrazolyl group, a 5-oxo-1,2,4-oxadiazolyl group, a 2-oxo-1,3,4-oxadiazolyl group, a 5-imino-4,5-dihydro-1,3,4-oxadiazolyl group, a 2-thioxo-1,3,4-oxadiazolyl group or a 5-oxo-1,2,4-thiadiazolyl group;
• wherein, R2, R3 and R4 represent each independently a hydrogen atom or a lower alkyl group;
• the <Substituent group L>, the <Substituent group M> and the <Substituent group N> are defined as described below.
• <Substituent group L>:
• a halogen atom, a hydroxyl group, a nitro group, a cyano group, a formyl group, an amino group, a carboxyl group, a lower alkyl group, a halo-lower alkyl group, a cycloalkyl group, a lower alkoxy group, a halo-lower alkoxy group, a hydroxy lower alkyl group, a lower alkoxy lower alkyl group, a lower alkoxycarbonyl group, a lower alkanoyl group, a lower alkylthio group, a lower alkylsulfonyl group, a lower alkylamino group, a di-lower alkylamino group, a carbamoyl group, a mono-lower alkyl carbamoyl group, a di-lower alkyl carbamoyl group, a lower alkanoylamino group, a lower alkylsulfonylamino group, a lower alkoxycarbonylamino group, an aralkyl group, an aryloxy group, a heteroaryloxy group, and a lower alkenyl group
• <Substituent group M>:
• a halogen atom, a hydroxyl group, a nitro group, a cyano group, a formyl group, an amino group, a carboxyl group, a lower alkyl group, a halo-lower alkyl group, a cycloalkyl group, a lower alkoxy group, a halo-lower alkoxy group, a hydroxy lower alkyl group, a lower alkoxy lower alkyl group, a lower alkoxycarbonyl group, a lower alkanoyl group, a lower alkylthio group, a lower alkylsulfonyl group, a lower alkylamino group, a di-lower alkylamino group, a carbamoyl group, a mono-lower alkyl carbamoyl group, a di-lower alkyl carbamoyl group, a lower alkanoylamino group, a lower alkylsulfonylamino group, and a lower alkoxycarbonylamino group
• <Substituent group N>:
• a hydroxyl group, a cyano group, a formyl group, a carboxyl group, a lower alkyl group, a halo-lower alkyl group, a cycloalkyl group, a lower alkoxy group, a halo-lower alkoxy group, a hydroxy lower alkyl group, a lower alkoxy lower alkyl group, lower alkoxycarbonyl group, a lower alkanoyl group, a carbamoyl group, a mono-lower alkyl carbamoyl group, and a di-lower alkyl carbamoyl group]
• or a pharmaceutically acceptable salt or ester of the compound.