Beta carboline derivatives useful in the treatment of proliferative disorders

A compound of any one of Formulas (Ia) or (Ib), or stereoisomeric forms thereof,

• wherein
• m is an integer selected from 0, 1 or 2;
• n is an integer selected from 0, 1 or 2;
• L1 is a direct bond, —O—, —S—, —NR8— or —(CR9aR9b)p—;
• and R8 is hydrogen or C1-6alkyl;
• and p is an integer selected from 1, 2, 3, 4, 5 or 6;
• and each R9a and R9b is independently hydrogen, C1-6alkyl, C1-6alkyloxy, C1-6alkylthio, C1-6alkylamino, hydroxy or halo, each group being optionally substituted with one or more substituents independently selected from halo, hydroxy, C1-4alkyloxy or oxo;
• L2 is a direct bond, —O—, —S—, —NR10— or —(CR11aR11b)q—;
• and R19 is hydrogen or C1-6alkyl;
• and q is an integer selected from 1, 2, 3, 4, 5 or 6;
• and each R11a and R11b is independently hydrogen, C1-6alkyl, C1-6alkyloxy, C1-6alkylthio, C1-6alkylamino, hydroxy or halo, each group being optionally substituted with one or more substituents independently selected from halo, hydroxy, C1-4alkyloxy or oxo;
• Z1 is a direct bond, —O—, —S— or —NR12;
• and R12 is hydrogen or C1-6alkyl;
• L3 is a direct bond or —(CR13aR13b)r—;
• and r is an integer selected from 1, 2, 3, 4, 5 or 6;
• and each R13a and R13b is independently hydrogen, C1-6alkyl, C1-6alkyloxy, C1-6alkylthio, C1-6alkylamino, hydroxy or halo, each group being optionally substituted with one or more substituents independently selected from halo, hydroxy, C1-4alkyloxy or oxo;
• Z2 is a direct bond, —O—, —S— or —NR14;
• and R14 is hydrogen or C1-6alkyl;
• L4 is a direct bond or —(CR15aR15b)s—;
• and s is an integer selected from 1, 2, 3, 4, 5 or 6;
• and each R15a and R15b is independently hydrogen, C1-6alkyl, C1-6alkyloxy, C1-6alkylthio, C1-6alkylamino, hydroxy or halo, each group being optionally substituted with one or more substituents independently selected from halo, hydroxy, C1-4alkyloxy or oxo;
• R1 is hydrogen, C1-8alkyl, C2-8alkenyl, C2-8alkynyl, C1-8alkyloxy, C1-8alkylthio, C1-8alkylamino, C3-8cycloalkyl, C3-8cycloalkylC1-6 alkyl, C3-8cycloalkyloxy, C3-8cycloalkylC1-6 alkyloxy, C3-8cycloalkylthio, C3-8cycloalkylC1-6alkylthio, C3-8cycloalkylamino, C3-8cycloalkylC1-6alkylamino, aryl, arylC1-6alkyl, aryloxy, arylC1-6alkyloxy, arylthio, arylC1-6alkylthio, arylamino, arylC1-6alkylamino, heterocyclyl, heterocyclylC1-6alkyl, heterocyclyloxy, heterocyclylC1-6alkyloxy, heterocyclylthio, heterocyclylC1-6alkylthio, heterocyclylamino, heterocyclylC1-6alkylamino, heteroaryl, heteroarylC1-6alkyl;
• heteroaryloxy, heteroarylC1-6alkyloxy, heteroarylthio, heteroarylC1-6alkylthio, heteroarylamino or heteroarylC1-6alkylamino, each group being optionally substituted with one or more substituents independently selected from halo, hydroxy, C1-4alkyl, C1-4alkyloxy, C1-4alkylamino, cyano, nitro or oxo;
• R2 is hydrogen, C1-8alkyl, C2-8alkenyl, C2-8alkynyl, C1-8alkyloxy, C1-8alkylthio, C1-8alkylamino, C3-8cycloalkyl, C3-8cycloalkylC1-6 alkyl, C3-8cycloalkyloxy, C3-8cycloalkylC1-6 alkyloxy, C3-8cycloalkylthio, C3-8cycloalkylC1-6alkylthio, C3-8cycloalkylamino, C3-8cycloalkylC1-6alkylamino, aryl, arylC1-6alkyl, aryloxy, arylC1-6alkyloxy, arylthio, arylC1-6alkylthio, arylamino, arylC1-6alkylamino, heterocyclyl, heterocyclylC1-6alkyl, heterocyclyloxy, heterocyclylC1-6alkyloxy, heterocyclylthio, heterocyclylC1-6alkylthio, heterocyclylamino, heterocyclylC1-6alkylamino, heteroaryl, heteroarylC1-6alkyl, heteroaryloxy, heteroarylC1-6alkyloxy, heteroarylthio, heteroarylC1-6alkylthio, heteroarylamino or heteroarylC1-6alkylamino, each group being optionally substituted with one or more substituents independently selected from halo, hydroxy, C1-4alkyl, C1-4alkyloxy, C1-4alkylamino, cyano, nitro or oxo;
• R3 is hydrogen, C1-8alkyl, C2-8alkenyl, C2-8alkynyl, C1-8alkyloxy, C1-8alkylthio, C1-8alkylamino, C3-8cycloalkyl, C3-8cycloalkylC1-6 alkyl, C3-8cycloalkyloxy, C3-8cycloalkylC1-6 alkyloxy, C3-8cycloalkylthio, C3-8cycloalkylC1-6alkylthio, C3-8cycloalkylamino, C3-8cycloalkylC1-6alkylamino, aryl, arylC1-6alkyl, aryloxy, arylC1-6alkyloxy, arylthio, arylC1-6alkylthio, arylamino, arylC1-6alkylamino, heterocyclyl, heterocyclylC1-6 alkyl, heterocyclyloxy, heterocyclylC1-6alkyloxy, heterocyclylthio, heterocyclylC1-6 alkylthio, heterocyclylamino, heterocyclylC1-6alkylamino, heteroaryl, heteroarylC1-6alkyl, heteroaryloxy, heteroarylC1-6alkyloxy, heteroarylthio, heteroarylC1-6alkylthio, heteroarylamino or heteroarylC1-6alkylamino, each group being optionally substituted with one or more substituents independently selected from halo, hydroxy, C1-4alkyloxy, C1-4alkylamino, cyano, nitro or oxo;
• R4 is hydrogen, C1-8alkyl, C2-8alkenyl, C2-8alkynyl, C1-8alkyloxy, C1-8alkylthio, C1-8alkylamino, C3-8cycloalkyl, C3-8cycloalkylC1-6 alkyl, C3-8cycloalkyloxy, C3-8cycloalkylC1-6 alkyloxy, C3-8cycloalkylthio, C3-8cycloalkylC1-6alkylthio, C3-8cycloalkylamino, C3-8cycloalkylC1-6alkylamino, aryl, arylC1-6alkyl, aryloxy, arylC1-6alkyloxy, arylthio, arylC1-6alkylthio, arylamino, arylC1-6alkylamino, heterocyclyl, heterocyclylC1-6 alkyl, heterocyclyloxy, heterocyclylC1-6alkyloxy, heterocyclylthio, heterocyclylC1-6 alkylthio, heterocyclylamino, heterocyclylC1-6alkylamino, heteroaryl, heteroarylC1-6alkyl, heteroaryloxy, heteroarylC1-6alkyloxy, heteroarylthio, heteroarylC1-6alkylthio, heteroarylamino or heteroarylC1-6alkylamino, each group being optionally substituted with one or more substituents independently selected from halo, hydroxy, C1-4alkyloxy, C1-4alkylamino, cyano, nitro or oxo;
• with the proviso that in formula Ia at least one of R1-L1-, R2-L2-, R3-L3-Z1— or R4-L4-Z2— is not hydrogen and in formula Ib at least one of R2-L2-, R3-L3-Z1— or R4-L4-Z2— is not hydrogen;
• R7 is hydrogen, C1-6alkyl or C1-6alkyloxy, optionally substituted with one or more substituents independently selected from halo, hydroxy, C1-4alkyloxy, aryl or oxo;
• R5 is halo, C1-6alkyl, C1-6alkyloxy, haloC1-6alkyl or haloC1-6alkyloxy;
• R6 is halo, C1-6alkyl, C1-6alkyloxy, haloC1-6alkyl or haloC1-6alkyloxy;
• X− is an organic or inorganic anion;
• or pharmaceutically acceptable addition salts, hydrates or solvates thereof.