Intrathecal hydromorphone solutions having improved stability
AssigneePiramal Critical Care, Inc.
InventorsJohn J. Foster, Thomas R. Prentice
Life of this patent
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Abstract
The present disclosure relates generally to a pharmaceutical solution comprising hydromorphone or a pharmaceutically acceptable salt thereof that is substantially free of buffer and optionally one or more other additives. The pharmaceutically acceptable salt may be hydromorphone hydrochloride. Also disclosed are methods for the manufacture and use of the solution.
Claims30
A sterile pharmaceutical solution comprising hydromorphone, a pharmaceutically acceptable salt thereof, or combinations thereof, wherein the solution is substantially free of buffer.
A sterile pharmaceutical solution consisting essentially of hydromorphone, a pharmaceutically acceptable salt thereof, or combinations thereof, and water.
A method for manufacturing a pharmaceutical solution, the method comprising combining hydromorphone, a pharmaceutically acceptable salt thereof, or combinations thereof in the absence of buffers with sterile water, and dissolving the hydromorphone, the pharmaceutically acceptable salt thereof, or combinations thereof to form the solution.
A method of treating pain in a subject, the method comprising administering intrathecally a sterile pharmaceutical solution comprising hydromorphone, a pharmaceutically acceptable salt thereof, or combinations thereof, wherein the solution is substantially free of buffer.
Dependencies are inferred from the claim text.