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US 2014/0005211 A1Published application
Derivatives of pyrazole-substituted amino-heteroaryl compounds
AssigneeConcert Pharmaceuticals, Inc.
InventorsBhaumik Pandya, Craig E. Masse, Ian Robert Silverman, Roger Tung
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Abstract
This invention relates to novel pyrazole-substituted amino-heteroaryl compounds of Formula I: and pharmaceutically acceptable salts thereof. This invention also provides compositions comprising a compound of this invention and the use of such compositions in methods of treating diseases and conditions that are beneficially treated by administering an inhibitor of anaplastic lymphoma kinase (ALK).
Claims31
A compound of Formula I:
- or a pharmaceutically acceptable salt thereof, wherein:
- R1 and R2 are each independently selected from Cl, CH3 and CD3;
- R3 is CH3 or CD3;
- X1a, X1b, X2a, X2b, X3a, X3b, X4a, X4b, and X5 are each independently selected from hydrogen and deuterium;
- Y1 is hydrogen or deuterium;
- and
- Y2 is hydrogen or deuterium;
- provided that when R1 and R2 are each independently selected from Cl and CH3, each or X1a, X1b, X2a, X2b, X3a, X3b, X4a, X4b, and X5 is hydrogen and each of Y1 and Y2 is hydrogen, then R3 is CD3.
5 more elements
The compound of any one of the preceding claims wherein R3 is CH3.
The compound of any one of the preceding claims wherein R3 is CD3.
Dependencies are inferred from the claim text.