Inhibitors of influenza viruses replication

A compound represented by Structural Formula (I):

• or a pharmaceutically acceptable salt thereof, wherein:
• X is —Cl, —Br, —F, —CN, —O(C1-4 alkyl), or C1-C6 aliphatic optionally substituted with one or more instances of J1;
• Z1, Z2, Z3, and Z4 are each and independently CR2 or N, provided that up to three N are selected for Z1, Z2, Z3, and Z4, and provided that when Z3 and Z4 are both CR2, then Z1 and Z2 are not N at the same time;
• Ring S is a 6-membered aromatic ring;
• Ring T is a C3-C10 carbocycle optionally further substituted with one or more instances of JT;
• Q1 is —C(O)—, —CO2—, —OC(O)—, —O(CRtRs)k—C(O)O—, —C(O)NR′—, —C(O)N(R′)—O—, —C(O)NRC(O)O—, —NRC(O)—, —NRC(O)NR′—, —NRCO2—,
• —OC(O)NR′—, —OSO2NR′—, —S(O)—, —SO2—, —SO2NR′—, —NRSO2—, —NRSO2NR′—, —P(O)(OR)O—, —OP(O)(ORa)O—, —P(O)2O—, —CO2SO2—, —B(O)2—, or —(CRtRs)p—Y1—;
• Y1 is —C(O)—, —CO2—, —OC(O)—, —O(CRtRs)k—C(O)O—, —C(O)NR′—, —C(O)N(R′)—O—, —C(O)NRC(O)O—, —NRC(O)—, —NRC(O)NR′—, —NRCO2—,
• —OC(O)NR′—, —OSO2NR′—, —S(O)—, —SO2—, —SO2NR′—, —NRSO2—, —NRSO2NR′—, —P(O)(OR)O—, —OP(O)(ORa)O—, —P(O)2O—, —B(O)2—, or —CO2SO2—;
• R1 is:
• i) —H;
• ii) a C1-C6 aliphatic group optionally substituted with one or more instances of JA;
• iii) a C3-C10 carbocyclic group or 4-10 membered heterocyclic group, each optionally and independently substituted with one or more instances of JB;
• or iv) a 6-10 membered aryl group or 5-10 membered heteroaryl group, each optionally and independently substituted with one or more instances of JC;
• optionally R1, together with R′ and the nitrogen to which they are attached, form a 4-8 membered heterocyclic group optionally substituted with one or more instances of J2;
• or
• optionally -Q1-R1 forms, together with Ring T, a 4-10 membered, non-aromatic, spiro ring optionally substituted with one or more instances of J4;
• and
• R2 is —H, halogen, —CN, —NO2, —C(O)NH2, —C(O)NH(CH3), —C(O)N(CH3)2, or C1-C6 aliphatic optionally substituted with one or more instances of J1;
• JA JB, and JT are each and independently oxo or JC;
• JC are each and independently selected from the group consisting of halogen, cyano, M, Ra, or Ra-M;
• M is independently selected from the group consisting of —ORb, —SRb, —S(O)Ra, —SO2Ra, —NRbRc, —C(O)Ra, —C(═NR)Rc, —C(═NR)NRbRc, —NRC(═NR)NRbRc, —C(O)ORb, —OC(O)Rb, —NRC(O)Rb, —C(O)NRbRc, —NRC(O)NRbRc, —NRC(O)ORb, —OCONRbRc, —C(O)NRCO2Rb, —NRC(O)NRC(O)ORb, —C(O)NR(ORb), —OSO2NRbRc,
• —SO2NRcRb, —NRSO2Rb, —NRSO2NRcRb, —P(O)(ORb)2, —OP(O)(ORb)2, —P(O)2ORb and —CO2SO2Rb;
• or
• optionally, two JT, two JA, two JB, and two JC, respectively, together with the atom(s) to which they are attached, independently form a 4-10-membered ring that is optionally substituted with one or more instances of J4;
• and
• Ra is independently:
• i) a C1-C6 aliphatic group optionally substituted with one or more substituents selected from the group consisting of halogen, cyano, hydroxy, oxo, —NH2, —NH(C1-C4 alkyl), —N(C1-C4 alkyl)2, —OCO(C1-C4 alkyl), —CO(C1-C4 alkyl), —CO2H, —CO2(C1-C4 alkyl), —O(C1-C4 alkyl), C3-C8 carbocyclic group optionally substituted with one or more instances of J2, 4-8 membered heterocyclic group optionally substituted with one or more instances of J2, 5-10 membered heteroaryl group optionally substituted with one or more instances of J3, and 6-10 membered aryl group optionally substituted with one or more instances of J3;
• ii) a C3-C8 carbocyclic group, or 4-8 membered heterocyclic group, each of which is optionally and independently substituted with one or more instances of J2;
• or
• iii) a 5-10 membered heteroaryl group, or 6-10 membered aryl group, each of which is optionally and independently substituted with one or more instances of J3;
• and
• Rb and Rc are each independently Ra or —H;
• or optionally, Rb and Rc, together with the nitrogen atom(s) to which they are attached, each independently form a 4-8 membered heterocyclic group optionally substituted with one or more instances of J2;
• Rt and Rs are each independently —H, halogen, or C1-C6 alkyl optionally substituted with one or more instances of J1, or optionally, Rt and Rs, together with the carbon atom to which they are attached, form a cyclopropane ring optionally substituted with one or more instances of methyl;
• R and R′ are each independently —H or C1-C6 alkyl optionally and independently substituted with one or more instances of J1, or optionally R and R′, together with the nitrogen to which they are attached, form a 4-8 membered heterocyclic group optionally substituted with one or more instances of J2;
• each J1 is independently selected from the group consisting of halogen, cyano, hydroxy, oxo, —NH2, —NH(C1-C4 alkyl), —N(C1-C4 alkyl)2, —OCO(C1-C4 alkyl), —CO(C1-C4 alkyl), —CO2H, —CO2(C1-C4 alkyl), —O(C1-C4 alkyl), and phenyl;
• each J2 is independently selected from the group consisting of halogen, cyano, hydroxy, oxo, —NH2, —NH(C1-C4 alkyl), —N(C1-C4 alkyl)2, —OCO(C1-C4 alkyl), —CO(C1-C4 alkyl), —CO2H, —CO2(C1-C4 alkyl), C1-C4 alkyl, C1-C4 haloalkyl, and —O(C1-C4 alkyl);
• each of J3 and J4 is independently selected from the group consisting of halogen, cyano, hydroxy, —NH2, —NH(C1-C4 alkyl), —N(C1-C4 alkyl)2, —OCO(C1-C4 alkyl), —CO(C1-C4 alkyl), —CO2H, —CO2(C1-C4 alkyl), C1-C4 alkyl, C1-C4 haloalkyl, and —O(C1-C4 alkyl);
• p is independently 1, 2, 3 or 4;
• and
• k is independently 1, 2, 3 or 4;
• and
• provided that Q1-R1 is not at the same carbon atom to which —NH group that is attached to Ring S is attached.