Benzimidazole derivatives: preparation and pharmaceutical applications

A method of treatment of a disorder selected from the group consisting of inflammatory disorders, immune system disorders, cardiovascular diseases, fibrotic diseases, vascular diseases, viral diseases, neurological diseases, parasitic diseases and proliferative disorders, the method comprising administering a therapeutically effective amount of a compound of formula:

• wherein
• R1 is selected from the group consisting of:
• H, and unsubstituted or substituted C1-C10 alkyl, alkenyl, alkynyl, haloalkyl, heteroalkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, cycloalkylalkyl, C4-C9 heterocycloalkylalkyl, arylalkyl, and heteroarylalkyl, each of which may be unsubstituted or substituted with one or more substituents independently selected from the group consisting of:
• halogen, ═O, ═S, —CN, —NO2, alkyl, alkenyl, alkynyl, haloalkyl, heteroalkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, hydroxy, hydroxyalkyl, alkoxy, alkoxyalkyl, alkylamino, acylamino, aminoalkyl, phenoxy, benzyloxy, alkylsulfonyl, arylsulfonyl, aminosulfonyl, —COOH, —C(O)OR5, —SH, — and acyl;
• R2 is selected from the group consisting of:
• H, halogen, and unsubstituted or substituted C1-C10 alkyl, alkenyl, alkynyl, haloalkyl, heteroalkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, cycloalkylalkyl, C4-C9 heterocycloalkylalkyl, arylalkyl, and heteroarylalkyl, each of which may be unsubstituted or substituted with one or more substituents independently selected from the group consisting of:
• halogen, ═O, ═S, —CN, —NO2, alkyl, alkenyl, alkynyl, haloalkyl, heteroalkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, hydroxy, hydroxyalkyl, alkoxy, alkoxyalkyl, phenoxy, benzyloxy, alkylamino, acylamino, aminoalkyl, alkylsulfonyl, arylsulfonyl, aminosulfonyl, —COOH, —C(O)OR5, —SH, and acyl;
• R3 is selected from the group consisting of H, C1-C6 alkyl, and acyl;
• X and Y are the same or different and are independently selected from the group consisting of:
• H, halogen, —CN, —NO2, —CF3, C1-C4 alkyl, —COR5, —SR6, —OR6, and —NR7R8;
• R5 is C1-C4 alkyl;
• R6 is C1-C4 alkyl;
• R7 and R8 are each independently selected from the group consisting of:
• H, C1-C4 alkyl, C4-C9 cycloalkyl, C4-C9 heterocycloalkyl, aryl, heteroaryl, arylalkyl and heteroarylalkyl;
• or a pharmaceutically acceptable salt thereof,
• to a patient in need thereof.