Novel 4-(Substituted Amino)-7H-Pyrrolo[2,3-d] Pyrimidines As LRRK2 Inhibitors

A compound of Formula I

• or a pharmaceutically acceptable salt thereof wherein
• R1 and R2 are each independently hydrogen, C1-C6alkyl, C3-C7cycloalkyl, a four to seven membered heterocycloalkyl which contains one to three heteroatoms selected from N, O and S;
• or a five to six membered heteroaryl which contains one to four heteroatoms selected from N, O and S, wherein the C1-C6alkyl, C3-C7cycloalkyl, four to seven membered heterocycloalkyl, or five to six membered heteroaryl are optionally substituted with one to three R6;
• or R1 and R2 taken together with the nitrogen to which they are attached are a four to seven membered heterocycloalkyl which optionally contains one to two additional heteroatoms selected from N, O and S, and optionally contains one double bond;
• a six to eleven membered heterobicycloalkyl which optionally contains one to two additional heteroatoms selected from N, O and S;
• or a six to twelve membered heterospirocycloalkyl which optionally contains one to two additional heteroatoms selected from N, O and S;
• and wherein the four to seven membered heterocycloalkyl, six to eleven membered heterobicycloalkyl or six to twelve membered heterospirocycloalkyl is optionally substituted with one to three R7;
• R3 is phenyl or a five to ten membered heteroaryl which contains one to four heteroatoms selected from N, O and S;
• wherein the phenyl and five to ten membered heteroaryl are optionally substituted with one to three R9 and wherein the phenyl is optionally fused with a C5-C6cycloalkyl or a five to six membered heterocycloalkyl which contains one to three heteroatoms selected from N, O and S and which is optionally substituted with oxo;
• R4 and R5 are each independently hydrogen or C1-C3alkyl;
• R6 at each occurrence is independently selected from C1-C3alkyl, C1-C3alkoxy, hydroxy, halo, —NRaRb, —C(O)NRaRb, or a four to seven membered heterocycloalkyl which contains one to three heteroatoms selected from N, O and S;
• R7 at each occurrence is independently selected from halo, hydroxy, cyano, —NRaRb, —C(O)NRaRb, C1-C6alkyl, C1-C6alkoxy, phenyl, a five to six membered heteroaryl containing one to four heteroatoms selected from N, O and S, or two R7 when attached to the same carbon and taken together can be oxo;
• wherein the C1-C6alkyl, phenyl and five to six membered heteroaryl are optionally substituted with one to three R8;
• R8 at each occurrence is independently hydroxy, halo, cyano, C1-C3alkoxy, NRaRb, C1-C3alkyl optionally substituted with one to three halo, C3-C7cycloalkyl, phenoxy optionally substituted with cyano, or a five to six membered heteroaryloxy containing one to four heteroatoms selected from N, O and S and which is optionally substituted with one or two halo or C1-C3alkyl;
• R9 at each occurrence is independently cyano, halo, hydroxy, C1-C3alkyl-S—, —CO2H, —C(O)NH2, —S(O)2NH2, C1-C3alkyl optionally substituted with one to three halo or hydroxy, or C1-C3alkoxy optionally substituted with one to three halo or hydroxy;
• and
• Ra and Rb at each occurrence are each independently hydrogen, C1-C6alkyl, C3-C7cycloalkyl or —C(O)C1-C6alkyl.