5-azaindazole compounds and methods of use

A compound selected from Formula I:

• and stereoisomers, geometric isomers, tautomers, and pharmaceutically acceptable salts thereof, wherein:
• R1 is a five-membered or six-membered heteroaryl, optionally substituted with one or more groups independently selected from F, Cl, Br, —CN, —NO2, OH, C1-C12 alkyl, —NH(C1-C12 alkyl), —N(C1-C12 alkyl)2, —O(C1-C12 alkyl), —S(C1-C12 alkyl), —S(O)2(C1-C12 alkyl), —S(O)2N(C1-C12 alkyl)2, —(C1-C12 alkylene)-(C3-C12 carbocyclyl), —(C1-C12 alkylene)-(C2-C20 heterocyclyl), —(C2-C8 alkenylene)-(C3-C12 carbocyclyl), —(C2-C8 alkenylene)-(C2-C20 heterocyclyl), C6-C20 aryl, —(C6-C20 arylene)-(C2-C20 heterocyclyl), —(C6-C20 arylene)-(C1-C12 alkylene)-(C2-C20 heterocyclyl), C3-C12 carbocyclyl, C2-C20 heterocyclyl, and C1-C20 heteroaryl, where alkyl, alkenyl, alkynyl, alkylene, carbocyclyl, heterocyclyl, aryl, and heteroaryl are optionally substituted with one or more groups independently selected from F, Cl, Br, I, —CH3, —CH2CH3, —CH(CH3)2, —CH2CH(CH3)2, —CH2NH2, —CH2CH2NH2, —CH2CHCH2NH2, —CH2CH(CH3)NH2, —CH2OH, —CH2CH2OH, —C(CH3)2OH, —CH(OH)CH(CH3)2, —C(CH3)2CH2OH, —CH2CH2SO2CH3, —CN, —CHF2, —CF3, —CO2H, —COCH3, —CO2CH3, —CO2C(CH3)3, —COCH(OH)CH3, —CONH2, —CONHCH3, —CON(CH3)2, —C(CH3)2CONH2, —NO2, —NH2, —NHCH3, —N(CH3)2, —NHCOCH3, —N(CH3)COCH3, —NHS(O)2CH3, —N(CH3)C(CH3)2CONH2, —N(CH3)CH2CH2S(O)2CH3, ═O, —OH, —OCH3, —OCH2CH3, —S(O)2N(CH3)2, —SCH3, —CH2OCH3, —S(O)2CH3, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, azetidinyl, azepanyl, oxetanyl, pyrrolidinyl, piperazinyl, piperidinyl, (piperidin-4-yl)ethyl), pyranyl, (piperidin-4-ylmethyl), morpholinomethyl, and morpholino;
• and
• R2 is phenyl or a six-membered heteroaryl, where the phenyl or the six-membered heteroaryl is optionally substituted with one or more groups independently selected from F, Cl, Br, —CN, —NO2, OH, C1-C12 alkyl, —NH(C1-C12 alkyl), —N(C1-C12 alkyl)2, —O(C1-C12 alkyl), —S(C1-C12 alkyl), —S(O)2(C1-C12 alkyl), —S(O)2N(C1-C12 alkyl)2, —(C1-C12 alkylene)-(C3-C12 carbocyclyl), —(C1-C12 alkylene)-(C2-C20 heterocyclyl), —O(C2-C20 heterocyclyl), —NH(C2-C20 heterocyclyl), —N(C1-C12 alkyl)(C2-C20 heterocyclyl), —(C2-C8 alkenylene)-(C3-C12 carbocyclyl), —(C2-C8 alkenylene)-(C2-C20 heterocyclyl), C6-C20 aryl, —(C6-C20 arylene)-(C2-C20 heterocyclyl), —(C6-C20 arylene)-(C1-C12 alkylene)-(C2-C20 heterocyclyl), C3-C12 carbocyclyl, C2-C20 heterocyclyl, and C1-C20 heteroaryl, where alkyl, alkenyl, alkynyl, alkylene, carbocyclyl, heterocyclyl, aryl, and heteroaryl are optionally substituted with one or more groups independently selected from F, Cl, Br, I, —CH3, —CH2CH3, —CH(CH3)2, —CH2CH(CH3)2, —CH2NH2, —CH2CH2NH2, —CH2CHCH2NH2, —CH2CH(CH3)NH2, —CH2OH, —CH2CH2OH, —C(CH3)2OH, —CH(OH)CH(CH3)2, —C(CH3)2CH2OH, —CH2CH2SO2CH3, —CN, —CHF2, —CF3, —CO2H, —COCH3, —CO2CH3, —CO2C(CH3)3, —COCH(OH)CH3, —CONH2, —CONHCH3, —CON(CH3)2, —C(CH3)2CONH2, —NO2, —NH2, —NHCH3, —N(CH3)2, —NHCOCH3, —N(CH3)COCH3, —NHS(O)2CH3, —N(CH3)C(CH3)2CONH2, —N(CH3)CH2CH2S(O)2CH3, ═O, —OH, —OCH3, —OCH2CH3, —S(O)2N(CH3)2, —SCH3, —CH2OCH3, —S(O)2CH3, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, azetidinyl, azepanyl, oxetanyl, pyrrolidinyl, piperazinyl, piperidinyl, (piperidin-4-yl)ethyl), pyranyl, (piperidin-4-ylmethyl), morpholinomethyl, and morpholino.