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US 2014/0005161 A1Published application
Phenyl amino pyrimidine bicyclic compounds and uses thereof
AssigneeYM Biosciences Australia Pty Ltd
InventorChristopher John Burns
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Abstract
The present invention relates to phenyl amino pyrimidine bicyclic compounds formula I which are inhibitors of protein kinases including JAK kinases. In particular the compounds are active against JAK1, JAK2, JAK3 and TYK2 kinases. The kinase inhibitors can be used in the treatment of kinase associated diseases such as immunological and inflammatory diseases including organ transplants; hyperproliferative diseases including cancer and myeloproliferative diseases; viral diseases; metabolic diseases; and vascular diseases.
Claims16
A compound of formula I
- wherein
- R1 is a substituted or unsubstituted bicyclic heterocyclyl;
- R2 is selected from H, halogen, substituted or unsubstituted C1-4 alkyl, CF3 substituted or unsubstituted C1-4 alkoxy, CON(R)2, CN and CO2R;
- R is selected from H and substituted or unsubstituted C1-4 alkyl,
- or an enantiomer thereof, a prodrug thereof or a pharmaceutically acceptable salt thereof.
2 more elements
A compound selected from
- 4-(2-((4-(1-oxa-6-azaspiro[3.3]heptan-6-yl)phenyl)amino)pyrimidin-4-yl)-N-(cyanomethyl)benzamide;
- 4-(2-((4-(2-oxa-6-azaspiro[3.3]heptan-6-yl)phenyl)amino)pyrimidin-4-yl)-N-(cyanomethyl)benzamide;
- (S)-4-(2-((4-(1-oxa-6-azaspiro[3.4]octan-6-yl)phenyl)amino)pyrimidin-4-yl)-N-(cyanomethyl)benzamide;
- (R)-4-(2-((4-(1-oxa-6-azaspiro[3.4]octan-6-yl)phenyl)amino)pyrimidin-4-yl)-N-(cyanomethyl)benzamide;
- (R)-4-(2-((4-(1-oxa-6-azaspiro[3.5]nonan-6-yl)phenyl)amino)pyrimidin-4-yl)-N-(cyanomethyl)benzamide;
- (S)-4-(2-((4-(1-oxa-6-azaspiro[3.5]nonan-6-yl)phenyl)amino)pyrimidin-4-yl)-N-(cyanomethyl)benzamide;
- 4-((2-(4-(1-oxa-7-azaspiro[3.5]nonan-7-yl)phenyl)amino)pyrimidin-4-yl)-N-(cyanomethyl)benzamide;
- 4-(2-((4-(6-oxa-3-azabicyclo[3.1.1]heptan-3-yl)phenyl)amino)pyrimidin-4-yl)-N-(cyanomethyl)benzamide;
- 4-(2-((4-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)phenyl)amino)pyrimidin-4-yl)-N-(cyanomethyl)benzamide;
- 4-(2-((4-((1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl)phenyl)amino)pyrimidin-4-yl)-N-(cyanomethyl)benzamide;
- and
- 4-(2-((4-((1R,4R)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl)phenyl)amino)pyrimidin-4-yl)-N-(cyanomethyl)benzamide;
- or an enantiomer thereof, a prodrug thereof or a pharmaceutically acceptable salt thereof.
10 more elements
Dependencies are inferred from the claim text.