Reduction in complement activation and inflammation during tissue injury by carotenoids, carotenoid analogs, or derivatives thereof
AssigneeCardax Pharmaceuticals, Inc.
InventorSamuel F. Lockwood
Life of this patent
Estimating the term…
Abstract
Administering water-soluble or dispersible synthetic analogs or derivatives of astaxanthin, lutein, zeaxanthin, or lycophyll and/or other carotenoids to a subject may reduce some of the adverse effects of inflammation in a body organ or tissue. The analogs or derivatives may be incorporated into pharmaceutical, over-the-counter, or nutraceutical preparations. Administration of the analogs or derivatives described herein may reduce deposition of inflammatory mediators such as C-reactive protein, complement system proteins or the membrane attack complex (MAC) in tissues. Reduced deposition of these molecules in tissues may reduce cell damage and/or lysis in the tissues.
Claims16
1-74. (canceled)
A method of reducing tissue damage associated with an inflammatory response in a subject comprising administering to a subject who would benefit from such treatment a therapeutically effective amount of a pharmaceutically acceptable formulation comprising a synthetic carotenoid analog or a carotenoid derivative having the structure;
- wherein each R6 is independently:
- -alkyl-N(R7)2;
- -aryl-N(R7)2;
- -alkyl-N+(R7)3;
- -aryl-N ‘(R7)3;
- -alkyl-CO 2R8 ;
- -aryl-CO2R8, -alkyl-CO2−;
- -aryl-CO2−;
- an amino acid;
- or a peptide;
- where R7 is hydrogen, alkyl, or aryl;
- where R8 is hydrogen.
Dependencies are inferred from the claim text.