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US 2014/0005123 A1Published application
Pharmaceutical compositions
AssigneesDebiopharm S.A., Novartis AG
InventorsElisabete Goncalves, Karin Rapp, Bertrand Sutter, Frank Stowasser, Bjoern Trupp, Sebastian Chabaut, Julien Thorens
Life of this patent
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Abstract
The invention provides lipid-based pharmaceutical compositions comprising alisporivir.
Claims15
A pharmaceutical composition for oral administration comprising alisporivir in an amount of about 15% to about 20% by weight of the composition, and water in an amount of about 2% to about 15% by weight of the composition.
A pharmaceutical composition for oral administration comprising:
- 1) alisporivir in an amount of about 5% to about 15% by weight of the composition;
- 2) a lipophilic component selected from the group consisting of medium chain triglycerides, corn oil mono-di-triglycerides, sorbitan monooleate, linoleoyl macrogolglycerides and oleic acid;
- 3) a surfactant selected from the group consisting of Macrogolglycerol hydroxystearate, Caprylocaproyl Macrogol-8 glycerides, Vitamin E Polyethylene Glycol Succinate and Glyceryl caprylate;
- 4) a hydrophilic component selected from the group consisting of ethanol, polyethyleneglycol, triethylcitrate, diethylene glycol monoethyl ether and propylene glycol.
1 more element
Dependencies are inferred from the claim text.