Injectable delivery system for heparan-binding growth factors
AssigneeUniversity of Delaware
InventorsCatherine B. Safran, Mary C. Farach-Carson, Xinqiao Jia, Padma P. Srinivasa, Amit Jha
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Abstract
A method for enhancing chondrogenesis in a subject in need thereof comprises administering to the subject an effective amount of a pharmaceutical composition comprising a growth factor bound to hyaluronic acid (HA)-based hydrogel particles (HGPs). The hyaluronic acid (HA)-based hydrogel particles (HGPs) are conjugated with a heparan sulfate proteoglycan (HSPG). Related medicaments and methods for preparing the medicaments are provided.
Claims20
A method for enhancing chondrogenesis in a subject in need thereof, comprising administering to the subject an effective amount of a pharmaceutical composition comprising a growth factor bound to hyaluronic acid (HA)-based hydrogel particles (HGPs), wherein the hyaluronic acid (HA)-based hydrogel particles (HGPs) are conjugated with a heparan sulfate proteoglycan (HSPG).
Dependencies are inferred from the claim text.