Polyheterocyclic compounds highly potent as hcv inhibitors

A compound represented by the formula Ib:

• and/or stereoisomers, solvates, hydrates, tautomers, pharmaceutically acceptable salts, or mixtures thereof,
• wherein:
• m=0, 1 or 2;
• n=0, 1 or 2;
• p=0, 1 or 2;
• q=0, 1 or 2;
• r=0, 1, 2 or 3;
• each dashed line “” is, independently, a single bond or double bond;
• wherein when D and E are connected by a single bond, D and E are each, independently, selected from the group consisting of O, S, amino, and —C(Ra)(Rb)-;
• and R10 is hydrogen, oxygen, halogen atom, cyano, trifluoromethyl, C1-C20 alkyl, C1-C20 alkoxy, C1-C20 alkylthio, C1-C20 alkoxycarbonyl, C1-C20 aminocarbonyl, C1-C20 carbonylamino, C6-C20 aryl, C6-C20 aryloxy, C6-C20 aryloxycarbonyl, or C2-C20 heterocyclic group;
• wherein when D and E are connected by a double bond, D and E each, independently, selected from the group consisting of N or —C(Rc)-;
• wherein when E1 and G are connected by a single bond, E1 and G are each, independently, selected from the group consisting of O, S, amino, and —C(Ra)(Rb)-;
• and R10 is hydrogen, oxygen, halogen atom, cyano, trifluoromethyl, C1-C20 alkyl, C1-C20 alkoxy, C1-C20 alkylthio, C1-C20 alkoxycarbonyl, C1-C20 aminocarbonyl, C1-C20 carbonylamino, C6-C20 aryl, C6-C20 aryloxy, C6-C20 aryloxycarbonyl, or C2-C20 heterocyclic group;
• wherein when E1 and G are connected by a double bond, E1 and G are each, independently, selected from the group consisting of N or —C(Rc)-;
• wherein when the dashed line connecting R10 to the macrocycle is a double bond, R10 is O or S;
• wherein when the dashed line connecting R10 to the macrocycle is a single bond, R10 is hydrogen, halogen atom, cyano, trifluoromethyl, C1-C20 alkyl, C1-C20 alkoxy, C1-C20 alkylthio, C1-C20 alkoxycarbonyl, C1-C20 aminocarbonyl, C1-C20 carbonylamino, C6-C20 aryl, C6-C20 aryloxy, C6-C20 aryloxycarbonyl, or C2-C20 heterocyclic group;
• Ra, Rb and Rc are each, independently, selected from the group consisting of hydrogen, halogen atom, cyano, nitro, C1-C20 alkyl, C3-C20 cycloalkyl, C6-C20 aryl, C1-C20 alkoxy, C1-C20 alkylthio, C1-C20 alkoxycarbonyl, C6-C20 aryloxy, C6-C20 aryloxycarbonyl, C2-C20 heterocyclic alkoxycarbonyl, C2-C20 heterocyclic aryl, C1-C20 alkylamino, C2-C20 heterocyclic amino, C6-C20 aryl amino, C1-C20 aminocarbonyl, C1-C20 amido, C1-C20 amidocarbonyl, C1-C20 carbonylamino, C1-C20 alkylsulfonamido, C2-C20 heterocyclic sulfonamido, C6-C20 arylsulfonamido, and C1-C20 aminosulfonamido group;
• wherein when r=0, E is nothing, and the D group is directly linked to the E1 group;
• L is oxygen, sulfur, —S(O)—, —S(O)2—, carbonyl, —C(Rb)(Rc)-, —C(Rb)=C(Rc)-, C1-C20 alkoxy, C2-C20 heterocyclyl, C2-C20 heterocyclic alkoxy, —N(Ra)-, C1-C20 aminocarbonyl, C1-C20 alkoxycarbonyl, C6-C20 aryl, C6-C20 aryloxy, or C6-C20 aryloxycarbonyl group, wherein Ra, Rb and Rc are as defined above;
• T is N, O or CH, wherein when T is O, R1 is not present;
• U is C;
• W is O or S;
• X is O, S or —NRa-, wherein Ra is defined above;
• Y is N or CH;
• Z is hydroxyl, C1-C20 alkyl, C3-C20 cycloalkyl, C1-C20 alkoxy, C3-C20 cycloalkoxy, C1-C20 alkylamino, C3-C20 cycloalkylamino, C2-C20 heterocyclic amino, C6-C20 aryl, C6-C20 arylamino, C4-C20 heteroarylamino, C1-C20 alkyl sulfonamido, C3-C20 cycloalkylsulfonamido, C6-C20 arylsulfonamido, C1-C20 alkoxy sulfonamido, C3-C20 cycloalkoxy sulfonamido, C1-C20 alkylamino sulfonamido, C3-C20 cycloalkylamino sulfonamido, C6-C20 arylamino sulfonamido, C1-C20 uramido, C1-C20 thioureido, C1-C20 phosphate, or C1-C20 borate;
• R1 and R2 are each, independently, selected from the group consisting of hydrogen, hydroxyl, amino, C1-C2 alkyl, C3-C20 cycloalkyl, C1-C20 alkoxy, C3-C20 cycloalkoxy, C1-C20 alkoxycarbonyl, C1-C20 alkylamino, C3-C20 cycloalkylamino, C2-C20 heterocyclic amino, C6-C20 arylamino, C1-C20 alkoxycarbonylamino, C6-C20 aryloxycarbonylamino, C1-C20 alkylsulfonamido, C3-C20 cycloalkylsulfonamido, C2-C20 heterocyclic sulfonamido, C6-C20 arylsulfonamido, and C1-C20 aminosulfonamido group;
• R3, R4, R5 and R6 are each, independently, selected from the group consisting of hydrogen, halogen, hydroxyl, cyano, nitro, C1-C20 alkyl, C3-C20 cycloalkyl, C1-C20 alkoxy, C1-C20 alkylamino, C2-C20 heterocyclicamino, C6-C20 aryl, C6-C20 arylamino, C1-C20 alkylsulfonamido, C2-C20 heterocyclic sulfonamido, and C6-C20 arylsulfonamido group;
• and
• R7, R8 and R9 are each, independently, selected from the group consisting of hydrogen, cyano, nitro, trifluoromethyl, C1-C20 alkyl, C1-C20 alkoxy, C1-C20 alkylthio, C1-C20 alkoxycarbonyl, C1-C20 aminocarbonyl, C1-C20 carbonylamino, C6-C20 aryl, C6-C20 aryloxy, C6-C20 aryloxycarbonyl, and C2-C20 heterocyclic group.