Sulfonamide derivatives and methods of use thereof for improving the pharmacokinetics of a drug

A compound having the formula (I):

• or a pharmaceutically acceptable salt thereof,
• wherein:
• A is a 5 or 6-membered heteroarylene group;
• W is N or —CH—;
• X is N or —C(R3)—;
• R1 is selected from —(C1-C6 alkylene)-aryl, —(C1-C6 alkylene)-(5 or 6-membered heteroaryl), —(C1-C6 alkylene)-O-aryl, —(C1-C6 alkylene)-O-(5 or 6-membered heteroaryl) and C3-C6 cycloalkyl, wherein any aryl, heteroaryl or C3-C6 cycloalkyl group can be optionally substituted with up to four R7 groups, which can be the same or different, and wherein said C3-C6 cycloalkyl group can be fused to a benzene ring and said fused benzene ring can be optionally substituted with up to four R7 groups, which can be the same or different;
• each occurrence of R2 is independently selected from H, C1-C6 alkyl, —OH, —O—(C1-C6 alkyl) and —(C1-C6 alkylene)-O—(C1-C6 alkyl);
• R3 is selected from H, C1-C6 alkyl, C1-C6 hydroxyalkyl and —CN, or R3 and an R2 group, together with the carbon atoms to which they are attached, can combine to form a cyclopropyl ring;
• R4 is H, or R4 and an R2 group, can join to form a group selected from —CH2—CH2—CH2—, —C(O)—O—CH2—, —CH2—O—CH2— and —CH2—N(R8)—CH2—;
• R5 is —NH(R6), 5 or 6-membered monocyclic heterocycloalkyl or 9 or 10-membered bicyclic heterocycloalkyl, wherein said 5 or 6-membered monocyclic heterocycloalkyl group can optionally form a spirocycle with a C3-C6 cycloalkyl group or another 5 or 6-membered monocyclic heterocycloalkyl group, and wherein said 5 or 6-membered monocyclic heterocycloalkyl group and said 9 or 10-membered bicyclic heterocycloalkyl group can be optionally substituted on one or more ring carbon atoms with up to four R7 groups, which can be the same or different, and wherein a ring carbon atom of a 5 or 6-membered monocyclic heterocycloalkyl group may be functionalized as a carbonyl group
• R6 is C1-C6 alkyl or 5 or 6-membered heteroaryl, wherein said C1-C6 alkyl group is optionally substituted with 1 or 2 groups, each independently being NH2 or halo, and wherein said 5 or 6-membered heteroaryl group can be optionally substituted with up to four R7 groups;
• each occurrence of R7 is independently selected from C1-C6 alkyl, 5 or 6-membered heterocycloalkyl, C1-C6 hydroxyalkyl, C1-C6 haloalkyl, halo, —CN, —N(R8)2, —CH2N(R8)2, —OR8, —C(O)OR8, —SR8, —S(O)2R8 and —C(O)N(R8)2, wherein said 5 or 6-membered heterocycloalkyl group can be optionally substituted with a group selected from C1-C6 alkyl, halo, C1-C6 hydroxyalkyl, C1-C6 haloalkyl, halo, —CN, —N(R8)2 and —OR8;
• and
• each occurrence of R8 is independently H or C1-C6 alkyl.