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US 2014/0005098 A1Published application
Igfbp-3 derivatives and uses thereof
AssigneeInserm (Institut National De La Sante Et De La Recherche Medicale)
InventorsJean-François Godeau, Yves Le Bouc
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Abstract
The present invention provides polypeptide derivatives of IGFBP-3 that are resistant to proteolytic cleavage. These IGFBP-3 derivatives are useful in a variety of therapeutic and diagnostic applications. Also provided are pharmaceutical compositions and kits comprising such IGFBP-3 derivatives and methods for using these derivatives for the treatment of a variety of disorders.
Claims19
An IGFBP-3 polypeptide derivative comprising an N-terminal domain, an intermediary domain and a C-terminal domain, wherein:
- the N-terminal domain comprises the amino acid sequence of the N-terminal domain of wild-type IGFBP-3, of a biologically active variant thereof or of a biologically active fragment thereof;
- the intermediary domain comprises a linker resistant to proteolytic cleavage;
- and
- the C-terminal domain comprises the amino acid sequence of the C-terminal domain of wild-type IGFBP-3, of a biologically active variant thereof or of a biologically active fragment thereof.
1 more element
Dependencies are inferred from the claim text.