Bioactive peptides and methods of using same
AssigneeCompugen Ltd.
InventorsRonen Shemesh, Zurit Levine, Amir Toporik, Chen Hermesh, Yossef Kliger, Eyal Gofer, Assaf Wool, Dvir Dahary, Yossi Cohen
Life of this patent
Estimating the term…
Abstract
Disclosed are peptide ligands for G-protein coupled receptors that are useful for treating disorders associated with G-protein coupled receptor activation.
Claims21
A method of treating a fibrotic disorder or a condition comprising administering to a subject in need thereof a therapeutically effective amount of a peptide less than 35 amino acids in length, wherein said peptide comprises the amino acid sequence AYAAFSV (SEQ ID NO:2).
The method of claim 2, wherein said peptide comprises an amino acid sequence selected from the group consisting of:
- (SEQ ID NO:
- 1)
- AYAAFSV-Amide
- (SEQ ID NO:
- 2)
- AYAAFSV;
- (SEQ ID NO:
- 3)
- GQKGQVGPPGAACRRAYAAFSV-Amide;
- (SEQ ID NO:
- 4)
- GQKGQVGPPGAACRRAYAAFSV;
- (SEQ ID NO:
- 5)
- GQKGQVGPPGAAVRRAYAAFSV-Amide;
- (SEQ ID NO:
- 6)
- GQKGQVGPPGAAVRRAYAAFSV;
- (SEQ ID NO:
- 7)
- GQKGQVGPPGAACRRAYAAFSVGRRAYAAFSV-Amide;
- (SEQ ID NO:
- 8)
- GQKGQVGPPGAACRRAYAAFSVGRRAYAAFSV;
- (SEQ ID NO:
- 9)
- GQKGQVGPPGAAVRRAYAAFSVGRRAYAAFSV-Amide;
- (SEQ ID NO:
- 10)
- GQKGQVGPPGAAVRRAYAAFSVGRRAYAAFSV;
- (SEQ ID NO:
- 11)
- AYAAFSVG;
- (SEQ ID NO:
- 12)
- GQKGQVGPPGAACRRAYAAFSVG;
- (SEQ ID NO:
- 13)
- GQKGQVGPPGAAVRRAYAAFSVG;
- (SEQ ID NO:
- 14)
- GQKGQVGPPGAACRRAYAAFSVGRRAYAAFSVG;
- (SEQ ID NO:
- 15)
- GQKGQVGPPGAAVRRAYAAFSVGRRAYAAFSVG;
- (SEQ ID NO:
- 20)
- GQKGQVGPPGAACQRAYAAFSVG;
- (SEQ ID NO:
- 21)
- GQKGQVGPPGAPCQRAYAAFSVG;
- (SEQ ID NO:
- 22)
- GQKGQVGPPGAPCQRAYAAFSVG;
- (SEQ ID NO:
- 23)
- GQKGQAGLPGAQCPRAYAAFSVG;
- (SEQ ID NO:
- 24)
- GQKGQPGPQGHSCKQLYAAFSVG;
- (SEQ ID NO:
- 25)
- GQKGSMGAPGERCKSHYAAFSVG;
- and
- (SEQ ID NO:
- 26)
- GQKGSMGAPGDHCKSQYAAFSVG.
Dependencies are inferred from the claim text.