Methods of treating inflammation
AssigneeCarolus Therapeutics, Inc.
InventorsJoshua Robert SCHULTZ, Benedikt VOLLRATH, Court TURNER
Life of this patent
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Abstract
Disclosed herein, in certain embodiments, are peptides for use in inhibiting the interactions of PF4 and RANTES. Further disclosed herein, are methods for treating an inflammatory disease, disorder, condition, or symptom. In some embodiments, the method comprises co-administering an agent that inhibits the interactions of PF4 and RANTES and a second active agent.
Claims24
An isolated peptide, its pharmacologically acceptable salts, derivatives, and conjugates,
- characterized in that the peptide has an amino acid sequence SEQ ID NO:
- 1, as indicated below:
- (SEQ ID NO:
- 1)
- C-X1-X2-YFYTS-X3-X4-X5-X6-X7-X8-X9-X10-X11-X12-X13-X14-X15-C
- where:
- X1 is chosen from the group containing lysine, glutamine, arginine, histidine and asparagine, or an amino acid deletion;
- X2 is chosen from the group containing glutamic acid, aspartic acid and glutamine, or an amino acid deletion;
- X3 is chosen from the group containing glycine, serine and alanine;
- X4 is chosen from the group containing lysine, leucine and arginine;
- X5 is chosen from the group containing serine, cysteine, glycine and threonine;
- X6 is chosen from the group containing proline and alanine;
- X7 is chosen from the group containing asparagine and glutamine;
- X8 is chosen from the group containing proline, tyrosine and glycine;
- X9 is chosen from the group containing glycine, alanine and serine;
- X10 is chosen from the group containing isoleucine, valine and asparagine;
- X11 is chosen from the group containing valine, isoleucine and asparagine;
- X12 is chosen from the group containing phenylalanine, tyrosine, isoleucine, valine, leucine and methionine;
- X13 is chosen from the group containing isoleucine, valine, leucine, methionine and phenylalanine;
- X14 is chosen from the group containing threonine, glycine, alanine, serine and tyrosine;
- X15 is chosen from the group containing arginine, lysine, alanine, glutamine, histidine and asparagine, or an amino acid deletion.
A method of treating an inflammatory disease, disorder, condition, or symptom, comprising administering to an individual in need thereof a therapeutically-effective amount of agent that inhibits interactions between RANTES and Platelet Factor 4.
A method of treating a disorder of a cardiovascular system, comprising co-administering to an individual in need thereof a synergistic combination of (a) a therapeutically-effective amount of an agent that inhibits the interaction between RANTES and Platelet Factor 4;
- and (b) a second active agent selected from an agent that treats a cardiovascular disorder.
Dependencies are inferred from the claim text.