Markers associated with cyclin-dependent kinase inhibitors
AssigneeNovartis AG
InventorsMichel Faure, Zhenhai Gao, James Sutton, Guoying Karen Yu
Life of this patent
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Abstract
The invention provides methods of monitoring differential gene expression of pharmacodynamic (PD) markers in a patient treated with a Cyclin Dependent Kinase Inhibitor (CDKI), methods of determining the sensitivity of a cell to a CDKI by measuring PD markers and methods of screening for candidate CKDI.
Claims32
A method of monitoring the response of a patient to treatment with a Cyclin Dependent Kinase Inhibitor (CDKI), the method comprising:
- a) administration of at least one CDKI;
- b) measuring differential gene expression of at least one pharmacodynamic (PD) marker selected from Table 2 in a biological sample obtained from a patient who has been administered the CDKI;
- and
- c) comparing the differential gene expression of the at least one PD marker with gene expression of the at least one PD marker in a control sample.
A method of determining the sensitivity of a cell to a Cyclin Dependent Kinase Inhibitor (CDKI), the method comprising:
- a) contacting a cell with at least one CDKI;
- b) measuring differential gene expression of at least one pharmacodynamic (PD) marker selected from Table 2 in the cell contacted with the CDKI;
- and
- c) comparing the differential gene expression with gene expression from an untreated or placebo treated control cell.
-40. (canceled)
A kit used in a method of monitoring the response of a patient to treatment with a CDKI, the method comprising:
- a) administration of at least one CDKI;
- b) measuring differential gene expression of at least one pharmacodynamic (PD) marker selected from Table 2 in a biological sample obtained from a patient who has been administered the CDKI;
- c) comparing the differential gene expression of the at least one PD marker with gene expression of the at least one PD marker in a control sample;
- and
- wherein the kit comprises reagents for carrying out step b).
Dependencies are inferred from the claim text.