DinQ-sRNA TYPE I TOXIN-ANTITOXIN SYSTEM FOR PLASMID MAINTENANCE
AssigneeOslo Universitetssykehus Hf
InventorsRagnhild Weel-Sneve, James Booth, Magnar Bjoras, Knut Ivan Kristiansen
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Abstract
The present invention relates to the use of a dinQ-sRNA type I toxin-antitoxin systems for plasmid maintenance. An embodiment of the present invention relates to the use of the dinQ-sRNA type I toxin-antitoxin system for the manufacture of a plasmid selection system. In another embodiment of the present invention is the sRNA selected from the group consisting of agrA and agrB. Aspects of the present invention also relates to medical uses of the plasmid selection system.
Claims15
A plasmid selection system comprising a dinQ-sRNA type I toxin-antitoxin system.
Use of a dinQ-sRNA type I toxin-antitoxin system for the manufacture of a plasmid selection system.
A phagemid comprising:
- (a) agrA and/or agrB,
- (b) a functionally equivalent subsequence of (a) of at least 70 nucleic acids, or
- (c) a functionally equivalent polypeptide with a sequence identity of at least 85% to (a) or (b).
Dependencies are inferred from the claim text.