US 2014/0004592 A1 · Dendrimer-Based Excipients for the Attenuation of Protein Aggregation

Abstract

One aspect of the invention is a salt comprising guanidinium groups, as shown in formula I. Another aspect of the invention is a salt comprising guanidinium groups, as shown in formula II. Another aspect of the invention is a salt comprising guanidinium groups, as shown in formula III. Another aspect of the invention is a salt comprising guanidinium groups, as shown in formula IV. Yet another aspect of the invention is a salt comprising guanidinium groups, as shown in formula I, II, III, and IV further comprising independently for each occurrence citrate, phosphate, or sulfate anion. Also disclosed are compositions comprising a protein and a salt comprising guanidinium groups, as shown in formula I, II, III, and IV. Also provided are methods of increasing shelf life of an aqueous solution of a protein and decreasing the amount of protein aggregation in an aqueous solution of a protein.

Claims24

Dependent claims

A salt, comprising a plurality of anions;

and a cation represented by formula I:
wherein, independently for each occurrence,
each anion is
Z is —CH2CH2—, —CH2CH2CH2—, —CH2CH2CH2CH2—, or —CH2CH2CH2CH2CH2—;
Y is —CH2—, —CH2CH2—, —CH2CH2CH2—, —CH2CH2CH2CH2—, or —CH2CH2CH2CH2CH2—;
X1 is
X2 is
and
X3 is

6 more elements

Dependencies are inferred from the claim text.

Dendrimer-Based Excipients for the Attenuation of Protein Aggregation

Life of this patent

Dendrimer-Based Excipients for the Attenuation of Protein Aggregation

Life of this patent

Abstract

Claims24