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AssigneeCj Cheiljedang Corporation
InventorsHyang Choi, Kyoung Min Lee, Min Sun Kang, Sung Hoo Jhon, Hye Won Um, Su Jin Choi, Han Won Lee, Soo An Shin
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The present invention relates to a putrescine-producing microorganism and a method for producing putrescine using the same. To be more specific, the present invention is directed to a microorganism given the ability to produce putrescine which is generated by blocking a biosynthetic pathway from ornithine to arginine, increasing the intracellular level of glutamate, enhancing the biosynthetic pathway of ornithine from glutamate, and introducing extracellular ornithine decarboxylase; and a method for producing putrescine by using the microorganism.
A putrescine-producing microorganism, wherein the microorganism is modified to have weakened activities of an ornithine carbamoyltransferase and a protein involved in glutamate export (NCgl1221) compared to the endogenous activities thereof, and an activity of ornithine decarboxylase (ODC) is introduced into the microorganism.
A method for producing putrescine, comprising the step of (i) obtaining a cell culture by culturing a putrescine-producing microorganism, wherein the microorganism is modified to have diminished activity of an ornithine carbamoyltransferase and a protein involved in glutamate export, i.e., NCgl1221 compared to the endogenous activity thereof, and an activity of ornithine decarboxylase (ODC) is introduced into the microorganism;
Dependencies are inferred from the claim text.