Loading patent…
AssigneeAlnylam Pharmaceuticals, Inc.
InventorsAnthony Rossomando, Muthiah Manoharan, Gregory Hinkle, Brian Bettencourt, John M. Maraganora, Stuart Pollard, David Kocisko, Shannon Hogan
Estimating the term…
The invention provides compositions and methods for producing an immunogenic agent from a host cell. In various embodiments, the immunogenic agent is a polypeptide, an antigen, a virus particle, or a vaccine In one aspect, the invention provides for a method for producing an immunogenic agent from a host cell. The method generally comprises contacting the cell with a RNA effector molecule, a portion of which is complementary to a target gene, maintaining the cell in a large-scale bioreactor for a time sufficient to modulate expression of the target gene, wherein the modulation enhances production of the immunogenic agent from the cell, and isolating the immunogenic agent from the cell.
A method for producing an immunogenic agent in a large scale host cell culture, comprising:
(canceled)
A method for production of an immunogenic agent in a cell, the method comprising:
(canceled)
22-143. (canceled)
Dependencies are inferred from the claim text.